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Basic information

CohesinDB ID: CDBP00420012

Locus: chr21-41457310-41463776

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, TC-71, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, BGO3, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 78% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.156

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 32%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, NME2, XBP1, FOXA1, RXRB, ZFHX2, KDM3A, HDGF, ATF3, BMI1, CTCFL, RUNX3, PRDM1, ZNF444, CBFB, MXD4, DPF1, PAX5, TP63, MAF, JMJD1C, ELF1, TRIM28, BCLAF1, ETV1, SNAI2, KLF6, TEAD1, SMAD5, ESR1, ZNF217, OCA2, USF2, JUN, CTCF, TCF12, BAF155, KLF1, MNT, DPF2, E2F6, IRF4, RFX5, DEK, ZNF512B, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GATAD2A, RBPJ, EED, TFAP2C, GLIS1, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, TOP2A, KDM4C, MTA2, ZBTB48, STAT1, SRF, GATAD1, SAP130, NBN, ERG2, ARID3A, ERG, HOXC5, ASCL1, OGG1, MYC, EZH1, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, XRCC5, ZNF614, IKZF1, NFE2, MIER3, NR2F6, RCOR1, VDR, NR3C1, CEBPB, ZNF750, CREB1, EZH2, GRHL2, GABPB1, ZHX2, SPI1, GATA2, ZNF644, GATAD2B, MXD3, FLI1, HCFC1, ZGPAT, MXI1, SMARCA5, DRAP1, RELB, NFIL3, ETV5, RUNX1, THAP11, SMC1A, CBX1, CEBPA, NKX2-2, LDB1, BCL6, SOX13, ZFX, SIN3A, AFF4, ZNF534, SMAD3, ZNF654, ERG3, SP5, TRIM22, RARA, CREBBP, ZBTB2, ZNF35, RUNX2, ARNT, BACH1, NFIB, ATF2, ZNF48, SMAD4, PBX3, FOS, CHD1, SUPT5H, HMGXB4, CDK8, MED1, CSNK2A1, ZEB1, PML, TEAD3, MYB, PIAS1, SMAD1, ZNF3, MBD1, STAT5A, USF1, BCL11A, NIPBL, TFAP2A, HNF4A, IKZF5, REST, ATF7, ASH2L, TCF3, FOXP1, AATF, SMC3, STAG1, STAG2, MLLT1, NFATC3, SKI, TRP47, PPARG, FOXA2, MTA3, ZNF207, TBL1X, NFATC1, E2F8, SS18, CHD2, GTF2B, WT1, EBF1, ZBTB33, MEF2C, CDK9, HOXB13, BCL3, ZNF580, KDM1A, YY1, RELA, TARDBP, MCM3, SP140, ZFP36, HIF1A, SKIL, BATF, MAX, NRIP1, ZNF143, GATA1, CEBPG, KDM5B, TP53, ZNF687, ZNF334, NFKB1, EGR2, ELF3, PHF5A, BRD2, ARRB1, NFKBIZ, AR, BHLHE40, ARID4B, RXR, EGLN2, RB1, HSF1, ZBTB26, BRD4, JUND, CLOCK, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): MX1,PRDM15,ABCG1,UMODL1,FAM3B,TMPRSS2,MX2,RIPK4,BACE2

Function elements

Human SNPs: Age-related_diseases,_mortality_and_associated_endophenotypes

Number of somatic mutations (coding): 495

Number of somatic mutations (non-coding): 19

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160179,

eachgene

Deatailed information for cohesin site CDBP00420012