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Basic information

CohesinDB ID: CDBP00420016

Locus: chr21-41472869-41473818

Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, GSE103477, GSE25021

Cell type: MCF-7, MDM, RPE, Fibroblast, HCT-116, RT-112, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 35%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, ZNF468, PGR, TRIM25, HMG20A, LCORL, E2F7, XBP1, FOXA1, SUZ12, RXRB, PBX2, MLL4, TFAP4, HNRNPK, HDGF, ATF3, NFIC, CTCFL, CHD7, ATF4, CBFB, TP63, MITF, ZNF320, ZNF736, MAF, KLF5, ELF1, TEAD1, ETV1, NFE2L2, RCOR2, ESR1, USF2, CTCF, TCF12, JUN, EP300, LMO1, SOX5, DPF2, PAX8, ZNF776, TEAD4, FOXA3, GATAD2A, RBPJ, TFAP2C, GLIS1, BRD1, MYCN, ZNF263, TOP2A, MTA2, ZNF317, ZBTB48, ZSCAN5A, STAT1, SAP130, ERG, OGG1, ETS1, MYC, SMARCA4, TOP1, RAD21, GRHL3, RXRA, PROX1, GABPA, STAT3, XRCC5, ZNF614, IKZF1, RCOR1, DNMT3B, NR2F6, NR3C1, CEBPB, ZNF750, CREB1, EZH2, GRHL2, GABPB1, ZHX2, SPI1, PCBP1, GATA2, GATAD2B, MXD3, FLI1, ZGPAT, SMARCA5, RELB, MRTFB, ZNF554, ETV5, RUNX1, BCL6, SMC1A, CEBPA, SIRT6, SOX13, ZFX, AFF4, SMAD3, PCBP2, TET2, ZNF770, ERG3, TRIM22, SMARCC1, TWIST1, CREBBP, ZNF384, PRPF4, RARA, NOTCH1, RUNX2, NFIB, DAXX, SOX11, PBX4, ARNT, ZNF48, SMAD4, PBX3, MAFB, NCAPH2, FOS, CHD1, MED1, TEAD3, ZEB1, KDM6B, SCRT2, PIAS1, SMAD1, ZNF3, MAFK, BCL11A, USF1, SP1, HNF4A, REST, ZNF479, ZBTB7A, ATF7, POU2F3, HNRNPLL, CTBP2, AATF, SMC3, ELL2, STAG1, NFATC3, TRP47, ZNF316, FOXA2, EBF1, SS18, ZNF600, ZSCAN16, WT1, MAFF, ZBTB33, CDK9, HOXB13, YY1, RELA, TARDBP, MCM3, SP140, ZIC2, SKIL, HIF1A, ZFP36, GATA3, TAL1, MAX, NRIP1, ZNF143, PLAG1, NCOA3, NR2F2, NR2F1, KDM5B, ZNF687, TP53, PKNOX1, ZNF334, MYOD1, EGR2, ELF3, BRD2, TBX21, BHLHE40, AR, RXR, HEXIM1, EGR1, TFIIIC, HSF1, IKZF2, BRD4, JUND, SCRT1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): UMODL1,ABCG1,MX2,TMPRSS2,PRDM15,FAM3B,RIPK4,BACE2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 228

Number of somatic mutations (non-coding): 76

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420016