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Basic information

CohesinDB ID: CDBP00420020

Locus: chr21-41477136-41478922

Data sourse: ENCSR000BLD, ENCSR000BTU, GSE206145-GSE177045, ENCSR230ZWH, GSE67783, GSE131956, GSE86191, GSE116868, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE206145, GSE68388, GSE25021, GSE97394, ENCSR917QNE

Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, MB157, Ishikawa, HUES64, GBM39, Liver, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 25%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, PGR, SMARCA2, SOX2, XBP1, FOXA1, SUZ12, MLL4, ZFHX2, TFAP4, ATF3, NFIC, ZFP64, CHD7, RUNX3, MORC2, MECOM, MITF, KLF5, TEAD1, TRIM28, ELF1, SNAI2, SAP30, ESR1, LMO2, USF2, CTCF, TCF12, EP300, BAF155, SOX5, GATA6, RYBP, E2F6, IRF4, E2F1, ZNF528, TEAD4, ZNF175, PDX1, TFAP2C, RBPJ, NANOG, CHD8, BRD1, BRD3, POU5F1, TOP2A, CDK7, MYCN, ZNF263, ZBTB48, ZSCAN5A, STAT1, SRF, SAP130, ERG2, SP4, TBP, HNF4G, ERG, ZBTB21, ASCL1, MYC, SMARCA4, KDM4A, RAD21, RXRA, PROX1, GABPA, STAT3, XRCC5, PRDM14, NR3C1, CEBPB, ESRRA, HNRNPL, KMT2A, CREB1, EZH2, GRHL2, ZHX2, HDAC2, GATA2, MXD3, FLI1, HCFC1R1, MRTFB, NCOA2, ZNF554, RUNX1, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SOX13, ZFX, SMAD3, TET2, ERG3, SMARCC1, CREBBP, RARA, NOTCH1, RUNX2, GATA4, ARNT, BACH1, PBX4, NFIB, ATF2, ZNF48, SMAD4, FOXM1, CHD1, HMGXB4, CDK8, FOS, MED1, TEAD3, ZEB1, KDM6B, MYB, USF1, SP1, NIPBL, BCL11A, HNF4A, TFAP2A, REST, ZBTB7A, ASH2L, CTBP2, TCF3, BCOR, FOXP1, SMC3, STAG1, TRP47, CBFA2T2, ZNF207, FOXA2, RBBP5, CHD2, HDAC6, SS18, ZNF600, WT1, ESR2, ZBTB33, CDK9, KDM1A, YY1, RELA, JUNB, SP140, ZIC2, HIF1A, PCGF1, TCF4, BHLHE22, GATA3, TAL1, MAX, NRIP1, ZNF143, CBX2, BCL11B, NCOA3, TCF7L2, NR2F1, KDM5B, TP53, ZNF334, MYOD1, EGR2, ELF3, T, AR, TAF1, YAP1, EGLN2, ZBTB26, HSF1, BRD4, JUND, MAZ, AHR

Target gene symbol (double-evidenced CRMs): TMPRSS2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000184012,

eachgene

Deatailed information for cohesin site CDBP00420020