Deatailed information for cohesin site CDBP00420035

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  • Basic information
  • CohesinDB ID: CDBP00420035
  • Locus: chr21-41509897-41510115
  • Data sourse: GSE67783, ENCSR635OSG
  • Cell type: Liver, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 0% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.978
  • Subunit: SA1,Rad21
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 89% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "14_ReprPCWk": 45%, "13_ReprPC": 41%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, NFIA, FOSL1, PGR, TRIM25, HMG20A, SOX2, HNF1A, XBP1, PATZ1, FOXA1, SUZ12, RBFOX2, RXRB, RING1B, PBX2, ZFHX2, KDM3A, TFAP4, ZBTB7B, THRB, ATF3, CTCFL, CHD7, ZNF444, ATF4, CBFB, MORC2, MXD4, ZNF189, SMARCE1, TP63, HDAC3, SFPQ, CDX2, MYOG, MAF, KLF5, TEAD1, ELF1, TRIM28, KLF6, SNAI2, ETV1, RBM39, RCOR2, ESR1, OCA2, ZNF217, LMO2, SAP30, CTCF, JUN, TCF12, EP300, BAF155, KLF1, MNT, SOX9, SOX5, GATA6, RYBP, PAX8, E2F6, TRIM24, ZNF423, ZNF512B, E2F1, TEAD4, FOXA3, GATAD2A, GTF2F1, RBPJ, TFAP2C, EED, GLIS1, JARID2, PDX1, NANOG, POU2F2, BRD1, CHD8, MYCN, ZNF263, POU5F1, KDM4C, CTBP1, ERF, ZBTB17, DUX4, ZBTB48, STAT1, ZSCAN5A, ZSCAN21, ZNF134, SAP130, ARID3A, ERG2, SP4, TBP, HNF4G, ERG, HOXC5, ASCL1, OGG1, MYC, ONECUT1, SMARCA4, KDM4A, RFX1, RAD21, GRHL3, PROX1, RXRA, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, PRDM14, RB1, TERF2, NR2F6, HNRNPH1, VDR, INO80, NR3C1, CEBPB, ESRRA, HNRNPL, CREB1, ZNF560, EZH2, BMPR1A, GRHL2, ZNF652, TRPS1, GABPB1, PHF8, ZHX2, SPI1, TFE3, MIXL1, HDAC2, GATA2, INTS13, ZNF644, MXD3, ZNF121, FLI1, DRAP1, ZGPAT, NFIL3, NCOA2, ZIM3, ZNF554, ETV5, PTBP1, RUNX1, THAP11, CTNNB1, BCL6, SMC1A, CEBPA, CBX1, EZH2phosphoT487, NKX2-2, SOX13, ZFX, SIN3A, SIRT6, HDAC1, SMAD3, ZNF770, ERG3, SP5, SMARCC1, RARA, CREBBP, ZNF384, ZBTB2, TAF15, RUNX2, GATA4, OSR2, GR, SP3, NRF1, PBX4, ARNT, DAXX, ZNF48, SMAD4, MAFB, NCAPH2, FOS, CHD1, ZNF10, SP2, MED1, CSNK2A1, TEAD3, ZEB1, SPDEF, MYB, SCRT2, PIAS1, KDM6B, NR1H2, KLF9, MAFK, SP1, TFAP2A, NIPBL, HNF4A, IKZF5, REST, NKX2-5, ARID1A, ZBTB7A, ASH2L, HNRNPLL, PCGF2, PHIP, BCOR, FOXP1, MBD2, GLIS2, AATF, CTBP2, SMC3, NCOR2, STAG1, STAG2, PAX7, TRP47, CBFA2T2, PPARG, FOXA2, AGO1, CREM, RBBP5, HDAC6, TBL1X, MIER2, ZNF600, CHD2, WT1, ESR2, ZBTB33, TCF7, CDK9, ZNF580, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, AHR, KAT2B, SP140, ZIC2, HIF1A, TCF4, PCGF1, GATA3, KLF15, TAL1, MAX, MAF1, NRIP1, ZNF143, GATA1, MTA1, AGO2, TLE3, CEBPG, KLF4, SP7, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, ZNF687, PKNOX1, ZNF334, MYOD1, EGR2, ELF3, PHF5A, KAT8, BRD2, ARID4B, AR, TAF1, ZNF579, RXR, EGLN2, EGR1, HEXIM1, TFIIIC, ZBTB26, NCOR1, NOTCH3, BRD4, SCRT1, JUND, HSF1, CUX1, MAZ, RNF2, DMAP1, FOSL2
  • Target gene symbol (double-evidenced CRMs): MX2,MX1,PRDM15,TMPRSS2,RIPK4,BACE2,FAM3B,ABCG1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 2
  • Related genes and loops
  • Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000160179,
  • Related loop: chr21:41275000-41300000~~chr21:41500000-41525000, chr21:41300000-41325000~~chr21:41500000-41525000, chr21:41400000-41425000~~chr21:41500000-41525000, chr21:41500000-41525000~~chr21:41600000-41625000, chr21:41500000-41525000~~chr21:41750000-41775000, chr21:41500000-41525000~~chr21:41775000-41800000, chr21:41500000-41525000~~chr21:42250000-42275000, chr21:41500000-41525000~~chr21:42300000-42325000,
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