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Basic information

CohesinDB ID: CDBP00420040

Locus: chr21-41520133-41522085

Data sourse: GSE25021, GSE72082, GSE68388, GSE206145-GSE177045

Cell type: MCF-7, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 43%, "15_Quies": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, XBP1, FOXA1, TFAP4, ZFP64, ZNF189, SMARCE1, HDAC3, CDX2, TEAD1, ETV1, KLF6, ESR1, OCA2, JUN, CTCF, TCF12, BAF155, EP300, LMO1, ZNF33A, E2F1, TFAP2C, POU2F2, ZSCAN5D, MYCN, POU5F1, TOP2A, ERF, ZSCAN5A, STAT1, ZNF205, HNF4G, ERG, ZNF341, MYC, RAD21, TOP1, GRHL3, RXRA, PROX1, GABPA, XRCC5, NKX3-1, VDR, NR3C1, CEBPB, ESRRA, EZH2, GRHL2, SPI1, KDM5A, IRF1, HDAC2, GATA2, NCOA2, RUNX1, SOX13, ZFX, SIN3A, ERG3, PRDM10, CREBBP, NOTCH1, GATA4, ARNT, SOX11, SMAD4, MAFB, CSNK2A1, ZEB1, MYB, PIAS1, ZMYM3, C11orf30, SETDB1, MAFK, TFAP2A, HNF4A, ARID1A, ASH2L, TCF3, FOXP1, SMC3, STAG1, CBFA2T2, ZNF316, FOXA2, PPARG, GTF2B, MAFF, WT1, HOXB13, KDM1A, YY1, RELA, ZNF19, SP140, ZIC2, HIF1A, GATA3, NRIP1, ZNF143, GATA1, TLE3, KLF4, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, TP53, PKNOX1, NFKB1, MYOD1, AR, RXR, EGLN2, ZBTB42, BRD4, JUND, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ABCG1,MX1,PRDM15,RIPK4,FAM3B,BACE2,TMPRSS2,MX2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420040