- Basic information
- CohesinDB ID: CDBP00420057
- Locus: chr21-41548755-41549570
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Data sourse: ENCSR000BTU, GSE67783, GSE86191, GSE98367, GSE120943, GSE25021
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Cell type: MCF-7, HCT-116, Monocytes, Ishikawa, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 43%,
"15_Quies": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, POU2F2, PGR, SMC1A, ZSCAN5D, ZNF263, MYCN, CHD8, ZFX, TEAD4, XBP1, NME2, DUX4, WT1, ZBTB48, FOXA1, ZNF662, YY1, RELA, NFIC, MYC, RAD21, ARNT, GRHL3, HIF1A, GATA3, STAT3, PAX5, FOXM1, MAX, ZNF143, CHD1, NR3C1, CEBPB, NCOA3, CREB1, TFAP2C, EZH2, LMO2, ESR1, OCA2, KDM5B, HDAC8, GRHL2, CTCF, TCF12, USF1, NIPBL, EP300, BCL11A, AR, GATA6, EGLN2, BRD4, SMC3, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): MX1,FAM3B,BACE2,MX2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183486,
ENSG00000157601,
- Related loop:
chr21:41275000-41300000~~chr21:41525000-41550000,
chr21:41275000-41300000~~chr21:41550000-41575000,
chr21:41375000-41400000~~chr21:41525000-41550000,
chr21:41425000-41450000~~chr21:41525000-41550000,
chr21:41425000-41450000~~chr21:41550000-41575000,
chr21:41525000-41550000~~chr21:43200000-43225000,