Deatailed information for cohesin site CDBP00420069

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  • Basic information
  • CohesinDB ID: CDBP00420069
  • Locus: chr21-41580516-41586056
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, GSE105028, GSE25021, GSE131606, GSE165895, GSE115602, ENCSR000BTU, ENCSR917QNE, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE118494, GSE98367, ENCSR000BLS, GSE206145, GSE85526, ENCSR635OSG, GSE97394, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE111913, ENCSR054FKH, GSE68388
  • Cell type: Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, IMR-90, DKO, HFFc6, H1-hESC, Monocytes, MB157, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HeLa, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 15% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.756
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 89% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 60%, "14_ReprPCWk": 13%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, TEAD1, OCA2, E4F1, SOX5, ZNF407, ZNF211, ZNF410, ZNF528, GATAD2A, NANOG, POU5F1, TOP2A, CTBP1, STAT1, ZNF563, SAP130, ERG, SMARCA4, RFX1, TOP1, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, DRAP1, ZNF785, HCFC1R1, RUNX1, CEBPA, NKX2-2, HDAC1, CRY1, TET2, ZNF473, SP5, MCM2, TRIM22, ZNF549, SMARCC1, ZXDC, SOX11, FOXM1, PIAS1, NR1H2, C11orf30, GSPT2, IKZF5, ARID2, RBM25, MBD2, ELL2, CBFA2T2, CBX3, ZNF207, CREM, WT1, JUNB, NEUROD1, ZNF510, MCM3, TCF4, ZNF311, PLAG1, KLF4, ZNF544, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, NCOR1, ZBTB26, ZNF316, ZNF621, XBP1, ATF3, THRB, ZFP64, WDHD1, TP63, CDC5L, ELF1, SNAI2, ZIK1, CTCF, JUN, MNT, DPF2, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, YBX1, PLRG1, ZNF239, MTA2, ZSCAN21, ZBTB48, NONO, SRF, DDX5, NBN, PHB2, ONECUT1, HOMEZ, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, CCAR2, KLF8, ARHGAP35, GRHL2, ZNF292, KDM5A, SSRP1, SMARCA5, NFIL3, THAP11, CTNNB1, SOX13, AFF4, ZNF18, DAXX, ARNT, NFIB, ZNF48, PRDM9, ZEB2, ETV6, MAFB, HMGXB4, TEAD3, ZNF680, USF1, SP1, TFAP2A, ATF7, ASH2L, CTBP2, SMC3, STAG1, MLLT1, TRP47, MTA3, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, ZNF19, KAT2B, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, ZNF334, KAT8, EGR1, BRD4, JUND, CBX5, PGR, TFAP4, BMI1, CHD7, ZNF444, MXD4, SMARCE1, KLF6, ZNF217, ESR1, TRIM24, PRKDC, POU2F2, ZBTB1, ASH1L, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, ZNF114, OGG1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, YBX3, EZH2, ZNF514, ZNF652, SPI1, HDAC2, GATAD2B, ATM, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, NFXL1, CREBBP, RARA, NFYC, ZNF169, ZNF518A, SMAD4, CDK8, CSNK2A1, ZEB1, ZMYM3, NCOA1, MAFK, HNF4A, NR4A1, REST, ARID1A, BCOR, FOXP1, AATF, NCOR2, PPARG, ZNF662, FOXO3, RELA, TARDBP, MAX, ZNF592, TCF7L2, NR2F1, KDM5B, ZNF791, PKNOX1, AR, YAP1, ZNF324, ZNF280D, DMAP1, AHR, MBD3, FOSL2, HMG20A, ZSCAN5C, SUZ12, ZFHX2, ZNF274, NFIC, ZBTB5, MECOM, HDAC3, CDX2, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, SOX6, ZNF512B, E2F1, TEAD4, FOXA3, ZNF175, EHMT2, CHD8, BRD1, MYCN, ID3, GATAD1, ARID3A, MCM5, RAD21, GRHL3, PROX1, ZNF614, XRCC5, ZNF667, ZNF639, ZNF750, TRPS1, HES1, ZNF664, EHF, TFE3, IRF1, ZGPAT, PTBP1, SMC1A, CBX1, ZFX, SMAD3, NOTCH1, RUNX2, GATA4, GR, ZNF184, PBX4, NRF1, FOS, MED1, MYB, SETDB1, NIPBL, PHF20, ZBTB7A, ZFP82, NCOA4, FOXA2, RBBP5, MIER2, ZBTB33, HOXB13, YY1, ZNF148, ZNF521, SP140, HIF1A, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, NFKBIZ, ZNF579, NOTCH3, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): TMPRSS2,BACE2,FAM3B,MX1,MX2,ABCG1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 20
  • Related genes and loops
  • Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000160179,
  • Related loop: chr21:41125000-41150000~~chr21:41575000-41600000, chr21:41275000-41300000~~chr21:41575000-41600000, chr21:41300000-41325000~~chr21:41575000-41600000, chr21:41350000-41375000~~chr21:41575000-41600000, chr21:41425000-41450000~~chr21:41575000-41600000, chr21:41450000-41475000~~chr21:41575000-41600000, chr21:41575000-41600000~~chr21:42275000-42300000, chr21:41575000-41600000~~chr21:42800000-42825000,
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