- Basic information
- CohesinDB ID: CDBP00420070
- Locus: chr21-41588945-41589916
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE105028, GSE121355, GSE25021, GSE131606, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, ENCSR000BLS, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR054FKH, GSE68388, GSE83726, GSE50893
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Cell type: MCF-7, GM12892, H1-hESC, Fibroblast, HCT-116, RH4, GM18505, Hep-G2, SNYDER, HUES64, GM19238, GM2255, SK-N-SH, Liver, HSPC, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: Mau2,SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 68%,
"14_ReprPCWk": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZBTB2, SMC1A, CREB1, ZFX, RAD21, ESR1, ZNF574, SRF, SMC3, CTCF, TCF12, ZNF143, STAG1, GABPB1
- Target gene symbol (double-evidenced CRMs): BACE2,ABCG1,MX1,MX2,TMPRSS2,FAM3B
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000183486,
ENSG00000157601,
ENSG00000184012,
ENSG00000160179,
- Related loop:
chr21:41125000-41150000~~chr21:41575000-41600000,
chr21:41275000-41300000~~chr21:41575000-41600000,
chr21:41300000-41325000~~chr21:41575000-41600000,
chr21:41350000-41375000~~chr21:41575000-41600000,
chr21:41425000-41450000~~chr21:41575000-41600000,
chr21:41450000-41475000~~chr21:41575000-41600000,
chr21:41575000-41600000~~chr21:42275000-42300000,
chr21:41575000-41600000~~chr21:42800000-42825000,