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Basic information

CohesinDB ID: CDBP00420076

Locus: chr21-41600668-41607029

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, GSE105028, GSE131606, GSE25021, GSE115602, ENCSR917QNE, ENCSR000BTU, GSE165895, GSE93080, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR635OSG, ENCSR767DFK, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS

Cell type: GM2610, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, K-562, HFFc6, DKO, H1-hESC, MB157, GM12878, GM2588, RT-112, HeLa-Tet-On, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 22% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.711

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 29%, "15_Quies": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, NFIA, PGR, ZNF496, HMG20A, SOX2, XBP1, FOXA1, HLF, SUZ12, RBFOX2, RXRB, MLL4, KDM3A, TFAP4, ATF3, NFIC, THRB, ZFP64, THAP1, RUNX3, WDHD1, ZNF444, CBFB, MXD4, ZNF189, PAX5, TP63, SFPQ, CDX2, ZNF467, TEAD1, ELF1, RBM39, KLF6, ETV1, RCOR2, ESR1, ZNF217, USF2, CTCF, JUN, TCF12, EP300, BAF155, SOX5, GATA6, DPF2, E2F6, DMAP1, IRF4, TRIM24, MED12, PRKDC, E2F1, FOXA3, ZNF175, GATAD2A, TFAP2C, RBPJ, MLX, POU2F2, NANOG, ZSCAN5D, MYCN, ZNF263, POU5F1, KDM4C, CTBP1, ZBTB48, ZSCAN5A, STAT1, GATAD1, DDX5, SAP130, TBP, ZNF300, ERG, HNF4G, OGG1, NFKB2, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, NR2F6, MIER3, VDR, HNRNPH1, NR3C1, ESRRA, CEBPB, SRSF3, HNRNPL, ZNF750, KMT2A, CREB1, TBL1XR1, GRHL2, ZNF652, TRPS1, GABPB1, ZHX2, SPI1, TFE3, HBP1, MIXL1, ZNF257, HDAC2, GATA2, SSRP1, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, SMARCA5, ZNF490, RELB, HCFC1R1, NFIL3, NCOA2, ATF1, PTBP1, ETV5, RUNX1, THAP11, BCL6, CBX1, SMC1A, CEBPA, SOX13, ZFX, FIP1L1, SIN3A, SMAD3, TET2, NFXL1, ERG3, SP5, SMARCC1, CREBBP, ZNF384, RARA, ZXDC, TAF15, BRD9, RUNX2, NFYC, ARNT, DAXX, PBX4, NRF1, NFIB, ZNF48, PRDM9, SMAD4, ATF2, PBX3, NCAPH2, FOXM1, FOS, HMGXB4, MED1, TEAD3, CEBPD, SCRT2, PIAS1, ZMYM3, ZNF3, NCOA1, MBD1, USF1, BCL11A, SP1, TFAP2A, HNF4A, NIPBL, IKZF5, REST, ZBTB7A, RBM25, ATF7, ASH2L, HNRNPLL, CTBP2, TCF3, BCOR, MBD2, FOXP1, AATF, SMC3, NCOR2, STAG1, SKI, TRP47, PPARG, FOXA2, TBL1X, EBF1, CREM, AGO1, MIER2, WT1, ESR2, TCF7, CDK9, HOXB13, ZNF580, FOXO3, KDM1A, YY1, RELA, TARDBP, SP140, ZFP36, HIF1A, ZIC2, GATA3, BATF, MAX, NRIP1, ZNF143, AGO2, PLAG1, TLE3, CEBPG, KLF4, NCOA3, NR2F2, ZNF512, NR2F1, TCF7L2, KDM5B, ZNF768, TP53, MED, ZNF334, NFKB1, MYOD1, ELF3, PHF5A, KAT8, TBX21, BHLHE40, AR, NFKBIZ, ARID4B, ZNF579, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, BRD4, JUND, CUX1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ABCG1,MX1,PRDM15,BACE2,ZBTB21,C2CD2,TMPRSS3,TMPRSS2,RIPK4,MX2,UMODL1,UBASH3A,FAM3B,RSPH1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 26

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188,

eachgene

Deatailed information for cohesin site CDBP00420076