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Basic information

CohesinDB ID: CDBP00420077

Locus: chr21-41607264-41617134

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 88% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.111

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 29%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, NFIA, PGR, ZNF496, HMG20A, SOX2, XBP1, FOXA1, HLF, SUZ12, RBFOX2, RXRB, MLL4, KDM3A, TFAP4, ATF3, NFIC, THRB, ZFP64, THAP1, RUNX3, WDHD1, ZNF444, CBFB, MXD4, ZNF189, PAX5, TP63, SFPQ, CDX2, ZNF467, TEAD1, ELF1, RBM39, KLF6, ETV1, RCOR2, ESR1, ZNF217, USF2, CTCF, JUN, TCF12, EP300, BAF155, SOX5, GATA6, DPF2, E2F6, DMAP1, IRF4, TRIM24, MED12, PRKDC, E2F1, FOXA3, ZNF175, GATAD2A, TFAP2C, RBPJ, MLX, POU2F2, NANOG, ZSCAN5D, MYCN, ZNF263, POU5F1, KDM4C, CTBP1, ZBTB48, ZSCAN5A, STAT1, GATAD1, DDX5, SAP130, TBP, ZNF300, ERG, HNF4G, OGG1, NFKB2, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, NR2F6, MIER3, VDR, HNRNPH1, NR3C1, ESRRA, CEBPB, SRSF3, HNRNPL, ZNF750, KMT2A, CREB1, TBL1XR1, GRHL2, ZNF652, TRPS1, GABPB1, ZHX2, SPI1, TFE3, HBP1, MIXL1, ZNF257, HDAC2, GATA2, SSRP1, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, SMARCA5, ZNF490, RELB, HCFC1R1, NFIL3, NCOA2, ATF1, PTBP1, ETV5, RUNX1, THAP11, BCL6, CBX1, SMC1A, CEBPA, SOX13, ZFX, FIP1L1, SIN3A, SMAD3, TET2, NFXL1, ERG3, SP5, SMARCC1, CREBBP, ZNF384, RARA, ZXDC, TAF15, BRD9, RUNX2, NFYC, ARNT, DAXX, PBX4, NRF1, NFIB, ZNF48, PRDM9, SMAD4, ATF2, PBX3, NCAPH2, FOXM1, FOS, HMGXB4, MED1, TEAD3, CEBPD, SCRT2, PIAS1, ZMYM3, ZNF3, NCOA1, MBD1, USF1, BCL11A, SP1, TFAP2A, HNF4A, NIPBL, IKZF5, REST, ZBTB7A, RBM25, ATF7, ASH2L, HNRNPLL, CTBP2, TCF3, BCOR, MBD2, FOXP1, AATF, SMC3, NCOR2, STAG1, SKI, TRP47, PPARG, FOXA2, TBL1X, EBF1, CREM, AGO1, MIER2, WT1, ESR2, TCF7, CDK9, HOXB13, ZNF580, FOXO3, KDM1A, YY1, RELA, TARDBP, SP140, ZFP36, HIF1A, ZIC2, GATA3, BATF, MAX, NRIP1, ZNF143, AGO2, PLAG1, TLE3, CEBPG, KLF4, NCOA3, NR2F2, ZNF512, NR2F1, TCF7L2, KDM5B, ZNF768, TP53, MED, ZNF334, NFKB1, MYOD1, ELF3, PHF5A, KAT8, TBX21, BHLHE40, AR, NFKBIZ, ARID4B, ZNF579, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, BRD4, JUND, CUX1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): C2CD2,RIPK4,ABCG1,MX2,MX1,PRDM15,FAM3B,TMPRSS2,TMPRSS3,UBASH3A,BACE2,UMODL1,ZBTB21,RSPH1

Function elements

Human SNPs: Amyotrophic_lateral_sclerosis_(sporadic)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 56

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188,

eachgene

Deatailed information for cohesin site CDBP00420077