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Basic information

CohesinDB ID: CDBP00420080

Locus: chr21-41620001-41623327

Data sourse: GSE206145-GSE177045, ENCSR501LQA, GSE116868, ENCSR330ELC, GSE165895, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, ENCSR199XBQ, GSE206145, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR495WGO, ENCSR217ELF, ENCSR853VWZ, ENCSR944ZCT, ENCSR676MJK, GSE111913, ENCSR537EFT, ENCSR000EDE, GSE68388, ENCSR748MVX

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hela-Kyoto, MB157, A-549, HeLa-S3, RT-112, HSPC, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 11% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 32%, "14_ReprPCWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, XBP1, FOXA1, SUZ12, ZNF28, MLL4, ZFHX2, ATF3, CBFB, TP63, ZNF736, ELF1, TEAD1, ZNF26, ZNF217, ESR1, OCA2, TP73, CTCF, JUN, EP300, MNT, PAX8, DPF2, E2F1, ZNF528, FOXA3, GTF2F1, GLIS1, JARID2, ZNF263, MYCN, RUNX1T1, KDM4C, BRD3, POU5F1, ZBTB48, ZSCAN5A, STAT1, ERG2, HOXC5, ERG, OGG1, ETS1, MYC, ONECUT1, SMARCA4, RAD21, GRHL3, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, VDR, NR3C1, CEBPB, SRSF3, ZNF750, CREB1, EZH2, GABPB1, ZHX2, SPI1, IRF1, ZNF182, GATAD2B, MXD3, FLI1, SMARCA5, HCFC1R1, RUNX1, ZFX, SMAD3, TET2, ERG3, NFXL1, RUNX2, CDK6, PBX4, DAXX, BACH1, SOX11, FOS, MED1, TEAD3, CEBPD, ZNF558, ZMYM3, ZNF3, NR1H2, SREBF2, HIF2A, MAFK, HNF4A, RBM25, HNRNPLL, TCF3, BCOR, AATF, SMC3, STAG1, NFATC3, TRP47, CBFA2T2, PPARG, FOXA2, ZNF600, WT1, ESR2, HOXB13, BCL3, KDM1A, YY1, RELA, JUNB, SP140, HIF1A, MAF1, MAX, GATA1, KLF4, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, ZNF687, EGR2, PHOX2B, BRD2, BHLHE40, AR, ZBTB40, HEXIM1, HSF1, ZBTB26, BRD4, JUND, MAZ, ZNF440, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TMPRSS2,UMODL1,ZBTB21,RIPK4,ABCG1,UBASH3A,TMPRSS3,C2CD2,PRDM15,FAM3B,MX1,RSPH1,MX2,BACE2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398, ENSG00000160179, ENSG00000160183, ENSG00000160185, ENSG00000160188,

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Deatailed information for cohesin site CDBP00420080