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Basic information

CohesinDB ID: CDBP00420082

Locus: chr21-41627233-41628368

Data sourse: GSE206145-NatGen2015, GSE165895

Cell type: Fibroblast, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 48%, "14_ReprPCWk": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MED1, KLF4, CEBPB, MYC, PBX4, DAXX, BRD4, PBX3, STAT3, MAX, TCF12, FOS, HOXC5

Target gene symbol (double-evidenced CRMs): WDR4,HSF2BP,RIPK4,PRDM15,UMODL1

Function elements

Human SNPs: Mild_to_moderate_chronic_kidney_disease

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160193, ENSG00000160207,

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Deatailed information for cohesin site CDBP00420082