Deatailed information for cohesin site CDBP00420084

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  • Basic information
  • CohesinDB ID: CDBP00420084
  • Locus: chr21-41634030-41636192
  • Data sourse: GSE206145-GSE177045, ENCSR501LQA, GSE116868, ENCSR330ELC, GSE165895, ENCSR000EFJ, ENCSR000BTU, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, GSE206145, GSE85526, ENCSR247LSH, ENCSR767DFK, ENCSR984DZW, ENCSR495WGO, ENCSR217ELF, ENCSR853VWZ, GSE111913, ENCSR335RKQ, GSE68388, ENCSR748MVX
  • Cell type: MCF-7, RPE, Fibroblast, Hela-Kyoto, HCT-116, HEKn, MB157, Ishikawa, A-549, IMR-90, RT-112, HSPC, HuCC-T1, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 11% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.844
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 89% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 37%, "14_ReprPCWk": 25%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, SMARCA2, SOX2, MEIS2, NME2, XBP1, PATZ1, FOXA1, SUZ12, PBX2, MLL4, ZFHX2, TFAP4, ZBTB7B, HDGF, TSC22D4, ATF3, ZC3H8, NFIC, INSM2, BMI1, ZFP64, CHD7, PRDM1, ZNF444, KLF14, ZNF189, SMARCE1, TP63, CDX2, ZNF467, ZNF629, KLF5, ELF1, TRIM28, TEAD1, KLF6, ETV1, NFE2L2, SNAI2, ZNF217, ESR1, HNF1B, TP73, OCA2, USF2, CTCF, TCF12, JUN, EP300, KLF1, BAF155, MNT, LMO1, GATA6, SOX9, DPF2, PAX8, E4F1, E2F6, SIX5, RFX5, GLI4, SOX6, DEK, ZNF423, ZNF512B, E2F1, NR5A2, TEAD4, ZNF92, GTF2F1, EHMT2, RBPJ, TFAP2C, GLIS1, YBX1, NANOG, CHD8, MYCN, BRD3, ZNF263, POU5F1, RUNX1T1, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, MTA2, ZBTB1, SRF, NONO, NBN, HIC1, ERG2, ARID3A, TBP, PHB2, ERG, HOXC5, CHD4, ASCL1, OGG1, ZNF341, ETS1, MYC, ZBTB8A, SMARCA4, TSHZ1, RFX1, RAD21, MCM5, GRHL3, RXRA, NKX2-1, PROX1, GABPA, APC, STAT3, UBN1, XRCC5, ZNF8, IKZF1, RCOR1, DNMT3B, ZNF639, PRDM14, VDR, ARNTL, NR3C1, CEBPB, ESRRA, ZNF750, CREB1, ARHGAP35, GRHL2, ZHX2, HES1, EHF, IRF1, KLF17, HDAC2, GATA2, GATAD2B, FLI1, MXI1, ZNF490, MRTFB, NCOA2, ZNF554, RUNX1, CTNNB1, SMC1A, CBX1, HDAC1, SIN3A, ZFX, AFF4, ZNF534, SMAD3, ZNF770, TET2, ERG3, ZNF16, SMARCC1, TWIST1, PRDM10, CREBBP, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, DAXX, NFIB, ARNT, ZNF48, PRDM9, ETV6, PBX3, FOXM1, SMARCB1, FOS, CDK8, CHD1, SNRNP70, MED1, ZEB1, CEBPD, MYB, SCRT2, SMAD1, NR1H2, KLF9, SETDB1, HIF2A, USF1, NIPBL, SP1, MAFK, GSPT2, BCL11A, HNF4A, TFAP2A, REST, ARID1A, ZBTB7A, ZHX1, ATF7, ZNF548, HNRNPLL, PHIP, MBD2, GLIS2, AATF, SMC3, ELL2, NCOR2, STAG1, MLLT1, TRP47, PPARG, FOXA2, ZNF207, EBF1, CHD2, PAF1, SS18, ZNF600, MTA3, WT1, ESR2, ZBTB33, HOXB13, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF610, SP140, TCF4, HIF1A, MCM3, ZIC2, OTX2, GATA3, MAF1, MAX, TAL1, NRIP1, ZNF143, MTA1, ZNF449, TOP2A, CBX2, KLF4, ZNF592, SP7, NCOA3, NR2F2, ZNF281, TCF7L2, NR2F1, KDM5B, ZNF791, TP53, ZBTB6, PKNOX1, ZNF687, ZNF334, NFKB1, MYOD1, EGR2, ZSCAN22, ELF3, BRD2, BCLAF1, BHLHE40, PAX3-FOXO1, AR, TAF1, RXR, YAP1, EGLN2, ZBTB42, HEXIM1, ZNF366, EGR1, HSF1, RNF2, NCOR1, BRD4, JUND, SCRT1, MAZ, ZSCAN23, BRCA1, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): RIPK4,WDR4,PRDM15,HSF2BP,UMODL1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 12
  • Related genes and loops
  • Related gene: ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160193, ENSG00000160207,
  • Related loop: chr21:39175000-39200000~~chr21:41625000-41650000, chr21:41625000-41650000~~chr21:41725000-41750000, chr21:41625000-41650000~~chr21:41750000-41775000, chr21:41625000-41650000~~chr21:41775000-41800000, chr21:41625000-41650000~~chr21:42100000-42125000, chr21:41625000-41650000~~chr21:42125000-42150000, chr21:41625000-41650000~~chr21:42825000-42850000, chr21:41625000-41650000~~chr21:43575000-43600000, chr21:41633498-41635738~~chr21:41653227-41655048,
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