Deatailed information for cohesin site CDBP00420088

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00420088
  • Locus: chr21-41640676-41643854
  • Data sourse: GSE72082, ENCSR501LQA, ENCSR000BLY, ENCSR000ECS, ENCSR330ELC, GSE108869, GSE165895, ENCSR000EFJ, GSE86191, GSE138405, GSE206145-NatGen2015, ENCSR806UKK, ENCSR199XBQ, ENCSR895JMI, ENCSR768DOX, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE83726, GSE126990, ENCSR748MVX
  • Cell type: RPE, Fibroblast, HCT-116, Hela-Kyoto, HEKn, Hep-G2, RH4, A-549, HeLa-S3, HeLa, IMR-90, SK-N-SH, RT-112, HuCC-T1, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 19% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.833
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 89% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 26%, "15_Quies": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, HMG20A, SOX2, FOXA1, HLF, MLL4, ATF3, NFIC, ZFP64, CHD7, PRDM1, RUNX3, PAX5, TP63, MITF, MYOG, KLF5, TEAD1, ELF1, ETV1, KLF6, NFE2L2, LMO2, ESR1, TP73, JUN, TCF12, CTCF, EP300, GATA6, DPF2, SOX4, IRF4, DEK, E2F1, ZNF528, TEAD4, TFAP2C, RBPJ, EED, GLIS1, ZSCAN5D, SRC, BRD3, CDK7, TOP2A, KDM4C, MYCN, MTA2, ZBTB17, DUX4, STAT1, SRF, SAP130, NBN, HOXC5, ERG, ZNF341, ETS1, MYC, SMARCA4, EOMES, RAD21, GRHL3, RXRA, NKX2-1, STAT3, XRCC5, SOX10, UBN1, IKZF1, RCOR1, VDR, ZNF750, CEBPB, NR3C1, ESRRA, CREB1, EZH2, GRHL2, EBF3, ZHX2, SPI1, EHF, IRF1, ZNF257, GATA2, GATAD2B, SIX2, FLI1, MXI1, RELB, MRTFB, NCOA2, NFIL3, ETV5, RUNX1, SMC1A, BCL6, CEBPA, ZBTB24, SIN3A, ZFX, AFF4, SMAD3, ZNF770, ERG3, CBX8, SMARCC1, TWIST1, CREBBP, ZNF35, RARA, ZNF384, RUNX2, SMAD2, GATA4, OSR2, ZNF184, PBX4, NRF1, DAXX, ATF2, HMBOX1, SMAD4, PBX3, FOXM1, FOS, CHD1, CDK8, MED1, TEAD3, SPDEF, MYB, TBX5, MAFK, BCL11A, SP1, USF1, HNF4A, NKX2-5, REST, ATF7, ASH2L, PHIP, PRDM6, ELL2, MLLT1, MEF2B, PPARG, FOXA2, EBF1, SS18, ZNF600, ZSCAN16, MAFF, WT1, ESR2, ZBTB33, CDK9, KDM1A, YY1, RELA, TARDBP, JUNB, SP140, HIF1A, GATA3, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, CBX2, KLF4, ZNF592, SP7, NCOA3, NR2F2, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, SMAD1-5-8, NFKB1, MYOD1, PHOX2B, BRD2, T, ELF3, KAT8, TBX21, BHLHE40, AR, TAF1, ZBTB40, ZBTB42, HEXIM1, ZNF366, HSF1, RNF2, IKZF2, BRD4, JUND, MAZ, BRCA1, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): HSF2BP,RIPK4,UMODL1,WDR4,PRDM15
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 15
  • Related genes and loops
  • Related gene: ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160193, ENSG00000160207,
  • Related loop: chr21:39175000-39200000~~chr21:41625000-41650000, chr21:41625000-41650000~~chr21:41725000-41750000, chr21:41625000-41650000~~chr21:41750000-41775000, chr21:41625000-41650000~~chr21:41775000-41800000, chr21:41625000-41650000~~chr21:42100000-42125000, chr21:41625000-41650000~~chr21:42125000-42150000, chr21:41625000-41650000~~chr21:42825000-42850000, chr21:41625000-41650000~~chr21:43575000-43600000, chr21:41633498-41635738~~chr21:41653227-41655048,
eachgene