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Basic information

CohesinDB ID: CDBP00420092

Locus: chr21-41650707-41652356

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE98367, GSE129526, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, GSE68388, GSE103477, GSE111537

Cell type: MCF-7, H1-hESC, Macrophage, Fibroblast, HCT-116, RPE, Hep-G2, THP-1, RT-112, OCI-AML-3, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 30%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, PGR, XBP1, FOXA1, ATF3, ZC3H8, ZNF444, TP63, ZNF736, JMJD1C, ESR1, CTCF, JUN, BAF155, TRIM24, KMT2B, TFAP2C, EED, POU2F2, MYCN, TOP2A, CTBP1, ZBTB48, ZSCAN5A, STAT1, ERG2, ERG, HOXC5, MYC, RFX1, RAD21, GRHL3, RXRA, GABPA, IKZF1, RCOR1, VDR, NR3C1, ESRRA, CEBPB, EZH2, GRHL2, ZHX2, SPI1, EHF, FLI1, SMARCA5, RELB, NCOA2, RUNX1, SMC1A, ZFX, POU4F2, SMAD3, TET2, ERG3, CBX8, CREBBP, RUNX2, GR, PBX4, DAXX, ETV6, FOS, CDK8, MED1, ZMYM3, NCOA1, BCL11A, RBM25, STAG1, TRP47, PPARG, EBF1, WT1, MEF2C, HOXB13, KDM1A, RELA, SP140, ZFP36, HIF1A, GATA3, NRIP1, CEBPG, ZNF141, NCOA3, NR2F2, NR2F1, KDM5B, ZNF334, ELF3, AR, ZBTB26, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): RSPH1,C2CD2,TFF2,TMPRSS3,TFF1,SLC37A1,RIPK4,UMODL1,PKNOX1,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160188, ENSG00000160190, ENSG00000160199,

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Deatailed information for cohesin site CDBP00420092