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Basic information

CohesinDB ID: CDBP00420093

Locus: chr21-41653070-41654701

Data sourse: ShirahigeLab-GSE177045, ENCSR230ZWH, ENCSR501LQA, ENCSR330ELC, GSE165895, GSE115602, GSE67783, GSE86191, GSE138405, ShirahigeLab-NatGen2015, ENCSR806UKK, ENCSR199XBQ, ENCSR895JMI, ENCSR768DOX, ShirahigeLab, ENCSR981FDC, ENCSR247LSH, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR495WGO, ENCSR217ELF, ENCSR853VWZ, ENCSR335RKQ, GSE68388, GSE126990, ENCSR748MVX

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hela-Kyoto, A-549, Liver, HSPC, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 14% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.889

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 32%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, ZNF426, ZNF697, XBP1, ZNF101, FOXA1, HDGF, NFIC, ZFP64, PRDM12, ZNF189, TP63, ZNF629, KLF5, TEAD1, TRIM28, ETV1, SNAI2, ESR1, TP73, JUN, TCF12, CTCF, EP300, ZNF577, ZNF157, DPF2, PAX8, IRF4, ZNF528, TEAD4, ZNF555, TFAP2C, GLIS1, CHD8, MYCN, MTA2, ZBTB48, DUX4, ZNF134, NBN, ARID3A, ERG, ZBTB21, ZBTB8A, ZNF341, MYC, SMARCA4, RAD21, GRHL3, RXRA, STAT3, IKZF1, RCOR1, NR3C1, CEBPB, ZNF750, ZBTB11, GRHL2, TRPS1, SPI1, ZNF664, EHF, FLI1, RELB, MRTFB, ZC3H11A, MYF5, RUNX1, SMC1A, CEBPA, AFF4, ZFX, SMAD3, ZNF654, TWIST1, SMARCC1, RUNX2, GATA4, GR, PBX4, ARNT, SOX11, ZNF781, ZNF518A, PBX3, ZNF10, FOS, MED1, KDM6B, CEBPD, ZXDB, ZNF680, SP1, TFAP2A, BCL11A, REST, ATF7, ZNF623, SMC3, ELL2, ZNF34, STAG1, ZNF394, PPARG, FOXA2, ZNF692, WT1, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF510, SP140, HIF1A, GATA3, BATF, TAL1, MAX, NR2F2, ZNF791, TP53, ZNF213, NFKB1, MYOD1, ZNF140, ELF3, TBX21, BHLHE40, AR, YAP1, EGLN2, HSF1, IKZF2, BRD4, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SLC37A1,UMODL1,RIPK4,TFF1,PKNOX1,B3GALT5,RSPH1,C2CD2,TFF2,TMPRSS3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160188, ENSG00000160190, ENSG00000160199,

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Deatailed information for cohesin site CDBP00420093