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Basic information

CohesinDB ID: CDBP00420094

Locus: chr21-41656820-41657981

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE111913, ENCSR703TNG, GSE115602

Cell type: MCF-7, RT-112, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: Mau2,SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 39%, "14_ReprPCWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, CHD8, BRD1, CBX1, RBBP5, SOX2, ZFX, CTBP1, TEAD4, SMAD3, ESR2, FOXA1, ZKSCAN1, RELA, CREBBP, MYC, CHD7, ARNT, HIF1A, NKX2-1, GATA3, STAT3, MAX, NRIP1, MED1, NR3C1, ESRRA, NCOA3, TEAD1, ZNF217, ESR1, OCA2, GRHL2, EGR2, JUN, EP300, TFAP2A, SP1, PAX3-FOXO1, AR, ZNF257, DPF2, HDAC2, YAP1, E2F6, EGLN2, ASH2L, BRD4, CTBP2, MAZ, NCOA2, TFAP2C

Target gene symbol (double-evidenced CRMs): TFF2,RIPK4,RSPH1,UMODL1,TFF1,SLC37A1,C2CD2,PKNOX1,TMPRSS3,B3GALT5

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160188, ENSG00000160190, ENSG00000160199,

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Deatailed information for cohesin site CDBP00420094