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Basic information

CohesinDB ID: CDBP00420095

Locus: chr21-41658412-41661789

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, GSE25021, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, GSE112028, ENCSR199XBQ, ENCSR703TNG, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR981FDC, ENCSR748MVX, ENCSR767DFK, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR167MTG, ENCSR853VWZ, ENCSR944ZCT, GSE110061, GSE129526, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, GSE68388, GSE126990, ENCSR000ECS

Cell type: HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, K-562, DKO, H1-hESC, Monocytes, MB157, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, HeLa, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 18% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.744

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 30%, "15_Quies": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, PGR, FOSL1, HMG20A, SOX2, FOXA1, ZFHX2, BMI1, ATF3, NFIC, ZFP64, ZNF362, CHD7, PRDM1, ZNF189, MITF, ZNF506, ELF1, TRIM28, TEAD1, KLF6, SNAI2, RBM39, ETV1, LMO2, ESR1, NFE2L2, OCA2, CTCF, JUN, TCF12, EP300, E4F1, SOX5, DPF2, E2F1, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, TFAP2C, POU2F2, CHD8, MYCN, CDK7, ZBTB48, ZSCAN5A, SAP130, ERG2, SP4, ERG, HOXC5, ETS1, MYC, SMARCA4, RFX1, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, PRDM14, IKZF1, MIER3, RCOR1, NR2F6, VDR, NR3C1, ESRRA, CEBPB, HNRNPL, GRHL2, GABPB1, ZHX2, SPI1, TFE3, ZNF644, GATAD2B, ZGPAT, HCFC1R1, ETV5, PTBP1, RUNX1, SMC1A, CBX1, CEBPA, SIRT6, AFF4, ZFX, SMAD3, TET2, ERG3, SMARCC1, ZBTB2, ZNF384, RARA, CREBBP, RUNX2, PBX4, DAXX, ZNF48, SMAD4, FOS, CDK8, SMARCB1, HMGXB4, MED1, TEAD3, MYB, SCRT2, MAFK, BCL11A, SP1, IKZF5, REST, ZBTB7A, ZNF479, POU2F3, ZNF605, AATF, SMC3, STAG1, ETV4, TRP47, AGO1, CHD2, WT1, MAFF, ESR2, ZBTB33, ZNF580, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, SP140, HIF1A, OTX2, GATA3, BATF, MAX, NRIP1, ZNF143, PLAG1, KLF4, NR2F2, NR2F1, KDM5B, TP53, ZNF334, MYOD1, EGR2, ELF3, AR, HSF1, ZBTB26, BRD4, JUND, SCRT1, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SLC37A1,RSPH1,C2CD2,TFF2,RIPK4,PKNOX1,UMODL1,TMPRSS3,B3GALT5,TFF1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 33

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160188, ENSG00000160190, ENSG00000160199,

eachgene

Deatailed information for cohesin site CDBP00420095