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Basic information

CohesinDB ID: CDBP00420096

Locus: chr21-41662180-41667516

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, GSE25021, ENCSR917QNE, GSE115602, ENCSR000BTU, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE51234, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE106870, GSE145327, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR981FDC, ENCSR620NWG, ENCSR748MVX, GSE97394, ENCSR217ELF, ENCSR000BTQ, GSE55407, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR000ECS

Cell type: MDM, RH4, GM19240, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, Monocytes, MB157, SK-N-SH, GM19239, RT-112, THP-1, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, Hep-G2, A-549, GM19238, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 31% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.567

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 25%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, MYCN, ZFX, NME2, ZBTB48, WT1, DUX4, FOXA1, TET2, YY1, RELA, ATF3, MYC, SP140, ZNF143, TEAD1, KDM5B, EGR2, CTCF, AR, HSF1, NCOR1, BRD4, STAG1

Target gene symbol (double-evidenced CRMs): TMPRSS3,TFF2,C2CD2,TFF1,SLC37A1,RIPK4,UMODL1,PKNOX1,B3GALT5,RSPH1

Function elements

Human SNPs: Keratinocyte_cancer_(MTAG)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 27

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160188, ENSG00000160190, ENSG00000160199,

eachgene

Deatailed information for cohesin site CDBP00420096