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Basic information

CohesinDB ID: CDBP00420098

Locus: chr21-41671179-41674646

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, GSE131606, GSE25021, GSE108869, GSE115602, GSE165895, ENCSR917QNE, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE98367, GSE206145, ENCSR000BTQ, GSE129526, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, ENCSR000ECS

Cell type: MCF-7, Macrophage, RPE, Hela-Kyoto, Fibroblast, HCT-116, MB157, Monocytes, HeLa-S3, RT-112, K-562, Liver, HSPC, HuCC-T1, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 31%, "14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: ZNF468, FOXO1, FOSL1, PGR, NME2, XBP1, FOXA1, SUZ12, HDGF, ATF3, THAP1, RUNX3, PRDM1, ZNF444, CBFB, TP63, ZSCAN4, ZNF736, CDC5L, JMJD1C, KLF5, TEAD1, ELF1, SNAI2, ESR1, USF2, CTCF, JUN, TCF12, LMO1, DPF2, ZNF410, ZNF512B, ZNF175, GTF2F1, TFAP2C, GLIS1, NANOG, CHD8, POU2F2, ZSCAN5D, MYCN, ZNF263, RUNX1T1, POU5F1, BRD1, ZSCAN21, ZNF317, ZBTB48, ZSCAN5A, SRF, DDX5, ERG2, ARID3A, ERG, ASCL1, OGG1, MYC, EZH1, SMARCA4, RAD21, GRHL3, STAT3, XRCC5, APC, NKX3-1, IKZF1, DNMT3B, VDR, NR3C1, CREB1, ARHGAP35, BMPR1A, GRHL2, GABPB1, ZHX2, SPI1, IRF1, ZNF257, HDAC2, GATA2, GATAD2B, FLI1, RUNX1, SMC1A, CBX1, SIRT6, ZFX, TET2, ERG3, RARA, ZNF384, TAF15, RUNX2, GATA4, GR, ARNT, NFIB, ZNF48, PRDM9, NCAPH2, FOS, SMARCB1, KDM6B, MYB, SCRT2, BCL11A, REST, ZNF605, HNRNPLL, CTBP2, TCF3, BCOR, AATF, SMC3, STAG1, MLLT1, TRP47, ZNF283, CBFA2T2, AGO1, FOXA2, TBL1X, ZNF600, WT1, CDK9, HOXB13, ZKSCAN1, YY1, RELA, TARDBP, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, GATA1, ZNF143, PLAG1, ZNF512, NR2F1, TCF7L2, KDM5B, TP53, ZNF334, AR, RXR, ZNF366, EGR1, HEXIM1, TFIIIC, HSF1, NCOR1, BRD4, SCRT1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): PKNOX1,UMODL1,TMPRSS3,RIPK4,RSPH1,C2CD2,B3GALT5,TFF2,SLC37A1,TFF1

Function elements

Human SNPs: Adverse_response_to_chemotherapy_in_breast_cancer_(alopecia)_(paclitaxel)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 17

Related genes and loops

Related gene: ENSG00000183778, ENSG00000183421, ENSG00000157617, ENSG00000177398, ENSG00000160181, ENSG00000160182, ENSG00000160183, ENSG00000160188, ENSG00000160190, ENSG00000160199,

eachgene

Deatailed information for cohesin site CDBP00420098