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Basic information

CohesinDB ID: CDBP00420108

Locus: chr21-41698776-41700406

Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, ENCSR703TNG, GSE25021

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hep-G2, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: Mau2,SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 45%, "14_ReprPCWk": 43%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NCOA2, TRIM25, PGR, BCL6, POU2F2, FOXA2, ZNF263, MYCN, TOP2A, SOX13, ZFX, CEBPA, CTBP1, SRC, ZBTB48, WT1, ESR2, FOXA1, ERG3, SP5, YY1, RELA, RARA, CREBBP, NOTCH1, RAD21, SP140, GRHL3, PRDM1, GATAD2A, GATA3, SMAD4, STAT3, MAX, NRIP1, PRDM14, NR2F6, MED1, NR3C1, CEBPB, CEBPG, NCOA3, TEAD3, NR2F2, MYB, TFAP2C, CHD8, ESR1, KLF9, CTCF, MNT, AR, SOX5, DPF2, ZNF644, HSF1, ZBTB26, MBD2, MAZ, NFIL3, SMC3, GTF2F1, STAG1, AHR

Target gene symbol (double-evidenced CRMs): SLC37A1,RSPH1,MX1,TMPRSS2,BACE2,PDE9A,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000160188, ENSG00000160190, ENSG00000160191,

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Deatailed information for cohesin site CDBP00420108