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Basic information

CohesinDB ID: CDBP00420111

Locus: chr21-41710305-41711418

Data sourse: GSE67783, GSE86191, GSE111913, GSE105028, GSE206145, GSE68388, GSE131606

Cell type: RPE, HCT-116, DKO, RT-112, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: NIPBL,SA1,Rad21,SMC1,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 32%, "13_ReprPC": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, KDM3A, TEAD1, OCA2, E4F1, SOX5, DEK, RFX3, ZNF555, GATAD2A, JARID2, NANOG, ZNF263, HHEX, TOP2A, POU5F1, CTBP1, STAT1, SAP130, ERG, ZBTB21, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, MXI1, HCFC1R1, RUNX1, CEBPA, NKX2-2, HDAC1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZXDC, ZBTB10, ATF2, FOXM1, SMARCB1, PIAS1, SMAD1, NR1H2, C11orf30, IKZF5, ARID2, RBM25, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, ZNF207, CREM, CHD2, WT1, JUNB, MCM3, ZFP36, BATF, PLAG1, KLF4, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, XBP1, HNF1A, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, WDHD1, TP63, MITF, ZNF467, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, DPF2, RYBP, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZSCAN21, ZNF317, ZBTB48, MTA2, ZBTB17, NONO, DDX5, NBN, TSHZ1, HOMEZ, KDM4A, RXRA, BATF3, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, CCAR2, TBL1XR1, KLF8, GRHL2, SSRP1, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, SOX13, ZNF770, ZNF18, SP3, ARNT, NFIB, DAXX, BACH1, ZNF48, ZEB2, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, U2AF1, USF1, SP1, TFAP2A, BCL11A, ZNF479, ATF7, ASH2L, CTBP2, SMC3, STAG1, ZNF394, TRP47, AGO1, MTA3, MAFF, ESR2, ZNF580, ZKSCAN1, KDM1A, BRG1, ZNF155, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, AGO2, CBX2, TP53, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, SMAD4.1D12, PGR, SOX2, PATZ1, RING1B, TFAP4, BMI1, CHD7, MXD4, SMARCE1, KLF6, ZNF217, ESR1, SAP30, KLF1, SOX9, ZNF260, E2F6, TRIM24, GTF2F1, POU2F2, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, SOX10, IKZF1, DNMT3B, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, ZNF182, GATAD2B, TAF9B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MYBL2, CREBBP, RARA, ZNF384, ZNF35, TAF15, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, NCOA1, RBM22, MAFK, HNF4A, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, TBL1X, ZNF692, ZNF662, TCF7, ZNF318, FOXO3, RELA, ZNF282, MAX, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, T, AR, RBAK, ZNF324, HEXIM1, AHR, FOSL2, DMAP1, HMG20A, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, KLF14, HDAC3, ZNF736, CDX2, ZNF629, ZNF506, KLF5, TRIM28, ETV1, ZNF26, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, GLI4, SOX6, E2F1, TEAD4, FOXA3, ZNF175, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, GATAD1, ARID3A, ASCL1, ZNF341, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF639, FEZF1, TFE3, EHF, ZNF664, IRF1, HBP1, ZGPAT, PTBP1, SMC1A, CBX1, MAFG, SIRT6, FIP1L1, ZFX, NFKBIA, SMAD3, PCBP2, IRF2, PRPF4, RUNX2, GATA4, OSR2, GR, ZNF184, PBX4, NRF1, NR2C1, FOS, TGIF2, MED1, KDM6B, CEBPD, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, PHIP, SKI, KLF13, FOXA2, RBBP5, ZNF600, MIER2, CDK9, HOXB13, YY1, SP140, HIF1A, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, ZNF579, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): TMPRSS2,RSPH1,BACE2,SLC37A1,MX1,FAM3B,PDE9A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000160188, ENSG00000160190, ENSG00000160191,

eachgene

Deatailed information for cohesin site CDBP00420111