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Basic information

CohesinDB ID: CDBP00420114

Locus: chr21-41715027-41718311

Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR150EFU, GSE25021, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE67783, GSE86191, GSE138405, GSE76893, GSE51234, ENCSR806UKK, GSE206145-NatGen2015, ENCSR199XBQ, ENCSR703TNG, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, GSE206145, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE129526, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE126990, ENCSR000ECS

Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hela-Kyoto, HEKn, Hep-G2, MB157, A-549, HeLa-S3, RT-112, K-562, Liver, GP5d, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 23% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 37%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, NFIA, PGR, HMG20A, SOX2, NME2, HNF1A, FOXA1, HLF, RBFOX2, RXRB, MLL4, ZFHX2, KDM3A, TFAP4, SIN3B, TSC22D4, BMI1, THRB, NFIC, ZFP64, ATF3, MORC2, MXD4, SMARCE1, TP63, CDX2, ZNF467, KLF5, TEAD1, TRIM28, ELF1, KLF6, SNAI2, NFE2L2, RCOR2, ESR1, HNF1B, ZNF217, TP73, CTCF, TCF12, JUN, EP300, E4F1, L3MBTL4, SOX5, GATA6, DPF2, E2F6, RFX5, DEK, RFX3, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, TFAP2C, MLX, GLIS1, BRD1, ZSCAN5D, ZNF263, MYCN, POU5F1, CTBP1, ZNF317, ZBTB48, ZSCAN5A, STAT1, GATAD1, SAP130, ARID3A, ERG2, TBP, HNF4G, ERG, PBX1, ETS1, MYC, RFX1, ARID1B, HOMEZ, RAD21, GRHL3, RXRA, PROX1, NKX2-1, MCRS1, GABPA, STAT3, XRCC5, ZNF614, IKZF1, RCOR1, HNRNPH1, MIER3, NR2F6, ZNF750, CEBPB, NR3C1, ESRRA, HNRNPL, CREB1, CCAR2, TBL1XR1, EZH2, GRHL2, ZNF652, TRPS1, GABPB1, SPI1, TFE3, MIXL1, HBP1, IRF1, HDAC2, ZNF644, GATAD2B, MXD3, SIX2, SREBF1, FLI1, DRAP1, ZGPAT, MXI1, NFIL3, NCOA2, ZNF554, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, CBX1, SOX13, ZFX, FIP1L1, SIN3A, SMAD3, TET2, TBX3, ERG3, SP5, SMARCC1, RARA, NFYC, CREBBP, PRPF4, ZXDC, ZNF384, CDK6, GATA4, ZNF184, PBX4, ARNT, ZNF48, SMAD4, FOXM1, FOS, HMGXB4, SMARCB1, TGIF2, MED1, TEAD3, ZEB1, CEBPD, MYB, U2AF1, ZNF3, NR1H2, RBM22, MAFK, SP1, NIPBL, TFAP2A, HNF4A, IKZF5, ARID2, REST, NKX2-5, RBM25, ZHX1, ASH2L, CTBP2, MBD2, FOXP1, TCF3, SMC3, ELL2, STAG1, SKI, PPARG, FOXA2, CREM, CHD2, MIER2, WT1, TCF7, CDK9, ZNF580, ZKSCAN1, BCL3, KDM1A, YY1, RELA, AHR, MCM3, SP140, TCF4, GATA3, TAL1, MAX, NRIP1, ZNF143, AGO2, CBX2, TLE3, CEBPG, KLF4, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, ZNF547, ZNF334, ZSCAN22, EGR2, ELF3, T, KAT8, PHF5A, ARID4B, NFKBIZ, AR, YAP1, EGR1, ZBTB26, RNF2, NCOR1, BRD4, JUND, SCRT1, CLOCK, CUX1, MAZ, ZNF24, DMAP1, FOSL2

Target gene symbol (double-evidenced CRMs): SLC37A1,PDE9A,BACE2,MX1,RSPH1,TMPRSS2,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 19

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000160188, ENSG00000160190, ENSG00000160191,

eachgene

Deatailed information for cohesin site CDBP00420114