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Basic information

CohesinDB ID: CDBP00420117

Locus: chr21-41721582-41723534

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE25021, ENCSR000EDW, ENCSR000BUC, GSE115602, ENCSR000BTU, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, ENCSR000EEG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000BTQ, ENCSR167MTG, GSE129526, ENCSR054FKH, GSE68388, GSE126755

Cell type: MCF-7, H1-hESC, Macrophage, Fibroblast, HCT-116, RPE, Hep-G2, MB157, Ishikawa, A-549, SK-N-SH, Neutrophil, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 61%, "13_ReprPC": 11%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, BCL6, FOXA2, NKX2-2, HMG20A, CEBPA, SOX2, ZFX, SMAD3, FOXA1, GATAD1, SAP130, PRDM10, RARA, HOMEZ, RAD21, CHD7, ZIC2, HIF1A, ARNT, DAXX, SMAD4, MAX, MED1, ZFP69B, CEBPB, TEAD3, EGR2, ELF3, MIXL1, IKZF5, MXD3, POU2F3, BRD4, FOXA3, GATAD2A

Target gene symbol (double-evidenced CRMs): PDE9A,FAM3B,RSPH1,SLC37A1,BACE2,TMPRSS2,MX1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000160188, ENSG00000160190, ENSG00000160191,

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Deatailed information for cohesin site CDBP00420117