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Basic information

CohesinDB ID: CDBP00420119

Locus: chr21-41725384-41728963

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, ENCSR000ECS, GSE121355, GSE131606, GSE108869, ENCSR000EDW, GSE25021, GSE165895, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR000BLS, GSE206145, GSE85526, ENCSR000ECE, ENCSR981FDC, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR748MVX

Cell type: HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, K-562, HFFc6, DKO, H1-hESC, MB157, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, A-549, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 30% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.700

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 89% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "13_ReprPC": 24%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, TRIM25, PGR, FOSL1, HMG20A, NME2, XBP1, KDM4B, FOXA1, SUZ12, RXRB, MLL4, ZFHX2, KDM3A, ATF3, THRB, NFIC, ZFP64, ZC3H8, CTCFL, CHD7, ZNF444, MORC2, CBFB, MXD4, TP63, MITF, ZNF736, MAF, KLF5, TEAD1, TRIM28, ELF1, RBM39, SNAI2, KLF6, ETV1, SAP30, ESR1, RCOR2, NFE2L2, TP73, OCA2, USF2, ZFP91, CTCF, TCF12, JUN, EP300, TAF3, MNT, SOX5, GATA6, RYBP, DPF2, SOX4, E2F6, DMAP1, E2F4, ZNF512B, E2F1, SMC1, RFX3, TEAD4, FOXA3, GATAD2A, PDX1, TFAP2C, EED, RBPJ, JARID2, GLIS1, MLX, NANOG, POU2F2, BRD1, ZSCAN5D, MYCN, POU5F1, ZNF263, BRD3, SRC, ZBTB48, ZSCAN5A, STAT1, NONO, SRF, GATAD1, SAP130, ERG2, TBP, ERG, HOXC5, OGG1, ETS1, MYC, MCM5, SMARCA4, KDM4A, HOMEZ, RAD21, RFX1, GRHL3, NKX2-1, GABPA, MCRS1, STAT3, ZNF614, XRCC5, APC, PRDM14, NKX3-1, RCOR1, DNMT3B, NR2F6, MIER3, NR3C1, ESRRA, CEBPB, ZNF750, HNRNPL, SRSF3, CREB1, EZH2, GRHL2, ZNF652, EBF3, TRPS1, GABPB1, PHF8, ZHX2, SPI1, TFE3, MIXL1, EHF, IRF1, ZNF257, PCBP1, HDAC2, ZNF644, GATAD2B, MXD3, FLI1, DRAP1, ZGPAT, HCFC1R1, NFIL3, MRTFB, ZNF554, NCOA2, PTBP1, ETV5, RUNX1, THAP11, SMC1A, BCL6, HDAC1, EZH2phosphoT487, SIRT6, CEBPA, SIN3A, ZFX, SOX13, AFF4, FIP1L1, SMAD3, PCBP2, TET2, ZNF770, ERG3, SP5, ZNF513, SMARCC1, RARA, CREBBP, ZBTB2, ZNF133, TAF15, RUNX2, CDK6, GATA4, ARNT, NFIB, DAXX, PBX4, NRF1, ZNF48, SMAD4, PBX3, NCAPH2, CHD1, FOS, CDK8, HMGXB4, SMARCB1, MED1, TEAD3, ZEB1, MYB, ZMYM3, U2AF1, ZNF3, NR1H2, MAFK, NIPBL, TFAP2A, SP1, HNF4A, BCL11A, USF1, IKZF5, REST, ZBTB7A, ASH2L, HNRNPLL, CTBP2, PHIP, BCOR, GLIS2, NKX2-2, AATF, SMC3, ELL2, STAG1, ETV4, SKI, TRP47, PPARG, AGO1, FOXA2, RBBP5, CHD2, SS18, EBF1, ZNF600, MIER2, WT1, ESR2, ZNF662, CDK9, ZNF580, KDM1A, YY1, RELA, TARDBP, JUNB, MCM3, SP140, ZIC2, HIF1A, PCGF1, BRCA1, GATA3, MAX, NRIP1, ZNF143, AGO2, CBX2, PLAG1, KLF4, CEBPG, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, MYOD1, EGR2, ELF3, PHF5A, KAT8, BRD2, ARID4B, AR, NFKBIZ, BHLHE40, YAP1, EGLN2, ZNF366, HEXIM1, EGR1, TFIIIC, HSF1, RNF2, ZBTB26, BRD4, JUND, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): FAM3B,PRDM15,MX1,UMODL1,BACE2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 29

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000141956, ENSG00000177398,

eachgene

Deatailed information for cohesin site CDBP00420119