- Basic information
- CohesinDB ID: CDBP00420121
- Locus: chr21-41733728-41735705
-
Data sourse: GSE67783, GSE86191, GSE116868, GSE111913, GSE206145, GSE206145-NatGen2015, GSE68388, GSE126755
-
Cell type: RPE, Fibroblast, HCT-116, MB157, RT-112, Neutrophil, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
89% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"14_ReprPCWk": 37%,
"15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, GLIS1, NFIA, TRP47, PGR, CHD8, BRD1, ZSCAN5D, ZNF263, MYCN, CRY1, POU5F1, ZFX, PAF1, ZNF317, ZBTB48, WT1, ZSCAN5A, TET2, ERG, YY1, RELA, ATF3, NFIC, MYC, THAP1, RAD21, SP140, NFIB, HIF1A, GABPA, TAL1, STAT3, FOS, NFE2, KLF4, ESRRA, PDX1, ZNF750, ELF1, ETV1, NR2F1, KDM5B, LMO2, ESR1, BMPR1A, GRHL2, ZNF334, MYOD1, EGR2, CTCF, ELF3, TCF12, SPI1, AR, ZNF257, ZNF479, E2F4, HSF1, FLI1, MAZ, NCOR2, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): MX1,PRDM15,BACE2,RIPK4,FAM3B,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 16
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000157601,
ENSG00000183421,
ENSG00000141956,
ENSG00000177398,
- Related loop:
chr21:41275000-41300000~~chr21:41725000-41750000,
chr21:41425000-41450000~~chr21:41725000-41750000,
chr21:41600000-41625000~~chr21:41725000-41750000,
chr21:41625000-41650000~~chr21:41725000-41750000,
chr21:41725000-41750000~~chr21:41825000-41850000,
chr21:41725000-41750000~~chr21:42075000-42100000,