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Basic information

CohesinDB ID: CDBP00420128

Locus: chr21-41750044-41752982

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE121355, GSE131606, GSE108869, ENCSR330ELC, ENCSR000EDW, GSE25021, ENCSR917QNE, GSE115602, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, GSE85526, ENCSR767DFK, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, GSE68388, ENCSR000ECS

Cell type: Liver, HuCC-T1, RPE, HMEC, Fibroblast, HEKn, HeLa-S3, HFFc6, H1-hESC, MB157, SK-N-SH, RT-112, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 24% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.789

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 28%, "5_TxWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, PGR, HMG20A, ZNF660, NME2, MEIS2, XBP1, PATZ1, FOXA1, HLF, SUZ12, RXRB, PBX2, ZNF28, ZFHX2, KDM3A, TFAP4, MLL4, TSC22D4, MEN1, ZNF90, ATF3, THRB, INSM2, ZFP64, NFIC, CHD7, KLF14, MXD4, ZNF189, SMARCE1, PAX5, TP63, CDX2, ZNF629, JMJD1C, MAF, TEAD1, TRIM28, ELF1, KLF6, SNAI2, RBM39, KLF10, RCOR2, ESR1, ZNF217, MLL, ETV1, SAP30, CTCF, JUN, TCF12, EP300, BAF155, MNT, SOX9, SOX5, DPF2, SOX4, DMAP1, E2F6, E2F4, E2F1, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, RBPJ, TFAP2C, GLIS1, BRD1, ZSCAN5D, MYCN, ZNF263, TOP2A, CTBP1, ZBTB17, ZBTB48, STAT1, ELK4, SRF, GATAD1, SAP130, DDX5, HNF4G, ERG, HOXC5, ZBTB21, ZBTB8A, ETS1, MYC, SMARCA4, TSHZ1, HOMEZ, RAD21, RXRA, NKX2-1, PROX1, GABPA, APC, XRCC5, ZNF614, STAT3, PRDM14, NKX3-1, MIER3, DNMT3B, HNRNPH1, NR2F6, ZNF639, RCOR1, NR3C1, CEBPB, ZNF750, ESRRA, CREB1, CCAR2, TBL1XR1, EZH2, BMPR1A, GRHL2, ZNF652, GABPB1, ZHX2, SPI1, MIXL1, TFE3, EHF, KLF17, IRF1, HDAC2, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, ZGPAT, MXI1, MRTFB, NFIL3, NCOA2, ZNF554, ETV5, PTBP1, RUNX1, THAP11, BCL6, SMC1A, CEBPA, CBX1, NKX2-2, EZH2phosphoT487, SOX13, ZFX, SIN3A, SIRT6, SMAD3, TET2, CBX8, TBX3, SP5, ZNF770, SMARCC1, PRDM10, RARA, PRPF4, ZNF384, CREBBP, ZNF35, RUNX2, OSR2, ZNF184, ARNT, DAXX, PBX4, NRF1, ZNF48, SMAD4, ZEB2, FOXM1, MAFB, SP2, FOS, HMGXB4, CDK8, CHD1, SMARCB1, MED1, PBX3, TEAD3, ZEB1, CEBPD, MYB, SCRT2, ZMYM3, PIAS1, ZNF3, NR1H2, KLF9, ZBTB18, MBD1, SREBF2, RBM22, MAFK, NIPBL, SP1, TFAP2A, HNF4A, USF1, IKZF5, REST, ARID1A, ZBTB7A, ASH2L, CTBP2, PHIP, FOXP1, AATF, SMC3, ELL2, STAG1, SKI, ZNF283, TRP47, CBFA2T2, PPARG, FOXA2, CREM, CHD2, PAF1, SS18, MIER2, ZNF600, WT1, MAFF, MEF2C, ZNF580, HOXB13, FOXO3, KDM1A, YY1, RELA, JUNB, BRG1, SP140, ZIC2, HIF1A, GATA3, MAX, NRIP1, ZNF143, AGO2, CBX2, CEBPG, KLF4, SP7, NR2F2, TCF7L2, NR2F1, KDM5B, NEUROG2, TP53, PKNOX1, ZNF687, ZNF334, NFKB1, MYOD1, EGR2, ZNF140, PHF5A, ELF3, KAT8, BRD2, ARID4B, NFKBIZ, AR, BHLHE40, ZNF324, EGLN2, ZBTB42, RB1, ZBTB26, HSF1, NCOR1, SCRT1, BRD4, JUND, RNF2, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): FAM3B,BACE2,MX2,PDXK,UMODL1,PDE9A,PRDM15,TMPRSS2,UBASH3A,MX1,RIPK4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 90

Number of somatic mutations (non-coding): 43

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160185, ENSG00000160191, ENSG00000160209,

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Deatailed information for cohesin site CDBP00420128