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Basic information

CohesinDB ID: CDBP00420134

Locus: chr21-41774945-41781439

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, T-47D, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, SC, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 84% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.144

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 29%, "13_ReprPC": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, ZBTB44, IKZF3, PAX5, ZNF320, SFPQ, TEAD1, LMO2, ZNF561, ZNF577, ARID5B, SOX5, PAX8, DEK, E2F4, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, UBN1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, EPAS1, BMPR1A, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, RELB, HCFC1R1, RUNX1, CEBPA, NKX2-2, HDAC1, REPIN1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, CBX4, ELK1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, NR1H2, MBD1, IKZF5, ARID2, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, CHD2, PAF1, SS18, WT1, MEF2C, JUNB, ZFP36, TCF4, MAF1, PLAG1, KLF4, ZNF784, ZFP69B, ZNF281, BCL11B, ZBTB6, BCL6B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, FOSL1, SMARCA2, ZNF660, HNF1A, XBP1, TSC22D4, ATF3, THRB, ZFP64, CBFB, ZNF273, TP63, MITF, ZNF467, JMJD1C, MYOG, ELF1, RBM39, SNAI2, KLF10, FUS, JUN, CTCF, TAF3, MNT, ZBTB20, LMO1, RYBP, DPF2, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, NBN, CHD4, ONECUT1, KDM4A, HOMEZ, TSHZ1, ZNF2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, AFF4, SOX13, ZNF770, ZNF18, SP3, DAXX, ARNT, BACH1, ZNF48, ZEB2, PBX3, NCAPH2, MAFB, HMGXB4, TEAD3, ZXDB, U2AF1, KLF9, ZBTB18, TBX5, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, PCGF2, GLIS2, PRDM6, ZNF623, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, EBF1, ESR2, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, ZNF141, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, SMAD4.1D12, PGR, SOX2, PATZ1, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, TP73, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ZNF24, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, GFI1, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, ZNF786, HDAC2, ZNF182, GATAD2B, ZNF777, ZNF76, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MYBL2, RARA, CREBBP, ZNF384, ZNF35, TAF15, NFYC, ZNF133, SMAD4, ZNF518A, CDK8, ZEB1, SPDEF, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, FOXO3, RELA, TARDBP, MAX, ZNF592, TCF7L2, NR2F1, KDM5B, ZNF791, NEUROG2, PKNOX1, MYOD1, T, AR, ZNF445, ZBTB16, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, MBD3, ZNF391, HMG20A, ZSCAN5C, SUZ12, RBFOX2, ZNF28, SFMBT1, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, ZNF736, CDX2, ZNF629, KLF5, TRIM28, ETV1, RCOR2, HNF1B, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, GATAD1, ARID3A, ZNF300, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ARNTL, ZNF750, FEZF1, TFE3, EHF, HBP1, IRF1, ZNF681, ZGPAT, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, PCBP2, CBX8, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, SMAD2, PBX4, NRF1, FOS, CHD1, TGIF2, MED1, CEBPD, MYB, SCRT2, KDM6B, ZNF3, HIF2A, KLF16, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ASXL1, SP140, HIF1A, BHLHE22, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): PRDM15,UBASH3A,FAM3B,C2CD2,BACE2,UMODL1,TMPRSS2,MX2,PDE9A,PDXK,CSTB,MX1

Function elements

Human SNPs: Venous_thromboembolism_adjusted_for_sickle_cell_variant_rs77121243-T

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 38

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000183486, ENSG00000157601, ENSG00000184012, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160185, ENSG00000160191, ENSG00000160209, ENSG00000160213,

eachgene

Deatailed information for cohesin site CDBP00420134