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Basic information

CohesinDB ID: CDBP00420135

Locus: chr21-41782169-41784881

Data sourse: GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, GSE121355, GSE73207, GSE131606, GSE108869, ENCSR330ELC, GSE25021, GSE115602, GSE165895, ENCSR000BTU, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, ENCSR000BLS, GSE206145, GSE85526, ENCSR247LSH, ENCSR495WGO, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: RH4, GM2610, HuCC-T1, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, K-562, HFFc6, DKO, TF-1, SK-N-SH, RT-112, HeLa-Tet-On, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, A-549, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 21% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.744

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 38%, "13_ReprPC": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, LMO2, OCA2, ZNF561, SOX5, PAX8, E2F4, DEK, ZNF528, NR5A2, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, BRD3, CTBP1, ERF, STAT1, SAP130, ERG, ZBTB8A, SMARCA4, ZNF8, UBN1, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, ELF4, MIXL1, GATA2, MXD3, SIX2, FLI1, HCFC1, DRAP1, RUNX1, CEBPA, HDAC1, NKX2-2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZNF549, ZBTB2, ZXDC, ZBTB10, FOXM1, SMARCB1, PML, PIAS1, SMAD1, NR1H2, MBD1, STAT5A, ARID2, IKZF5, MBD2, ELL2, NFATC3, CBFA2T2, CBX3, CREM, CHD2, NFATC1, SS18, PAF1, WT1, NEUROD1, JUNB, MCM3, ZFP36, PLAG1, KLF4, BCL11B, ZBTB6, ZNF765, RBM14, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, PBX2, HNRNPK, ATF3, ZFP64, WDHD1, CBFB, ZNF273, ZSCAN4, TP63, MITF, CDC5L, ZNF467, MAF, ELF1, RBM39, SNAI2, KLF10, ZNF624, CTCF, TAF3, JUN, MNT, LMO1, ZBTB20, DPF2, RYBP, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, ZNF317, NONO, SRF, DDX5, KDM4A, HOMEZ, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, KLF8, GRHL2, EBF3, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, LDB1, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZNF18, ARNT, DAXX, NFIB, ZNF48, ZEB2, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, TAF7, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, PCGF2, CTBP2, PRDM6, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, KLF7, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, CBX2, TP53, ZNF334, NFKB1, ZSCAN22, PHF5A, BRD2, KAT8, ARRB1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, PGR, SOX2, PATZ1, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX9, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, KDM4C, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, EZH2, ZNF652, SPI1, PCBP1, HDAC2, GATAD2B, NFYB, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, ZNF35, CREBBP, TAF15, NFYC, SMAD4, CBFA2T3, CDK8, ZEB1, ZNF264, NCOA1, SREBF2, ZNF22, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, ZNF574, RELA, TARDBP, MAX, ZNF730, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, ZNF324, HEXIM1, AHR, FOSL2, MBD3, HMG20A, ZSCAN5C, MEIS2, SUZ12, ZFHX2, ZNF274, INSM2, NFIC, ZNF362, ZBTB5, CTCFL, PRDM1, ZNF736, HDAC3, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, ZNF425, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, GATAD1, ARID3A, ASCL1, ZNF341, MCM5, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, JMJD6, FEZF1, HES1, TFE3, EHF, IRF1, ZGPAT, MRTFB, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, PCBP2, CBX8, TWIST1, NOTCH1, RUNX2, SMAD2, GATA4, OSR2, ZSCAN30, ZNF184, CDK6, NRF1, PBX4, GR, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, ZNF3, L3MBTL2, SETDB1, HIF2A, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, SKI, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, BRCA1, HIF1A, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): BACE2,FAM3B,TMPRSS2,UMODL1,C2CD2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 14

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000184012, ENSG00000157617, ENSG00000177398,

eachgene

Deatailed information for cohesin site CDBP00420135