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Basic information

CohesinDB ID: CDBP00420140

Locus: chr21-41796584-41797209

Data sourse: GSE206145-NatGen2015, GSE111913, GSE67783, GSE86191

Cell type: RT-112, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 68%, "15_Quies": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, PGR, CHD8, MYCN, PAF1, ZFX, ZBTB48, WT1, ZSCAN5A, FOXA1, TET2, LEO1, ZNF28, MYC, SP140, GRHL3, MAX, SUPT5H, AGO2, MAF, TEAD3, TEAD1, TRIM28, NCOA3, ESR1, OCA2, GRHL2, CTCF, RBM22, AR, MXD3, DEK, HSF1, SCRT1, MAZ, TEAD4, STAG1

Target gene symbol (double-evidenced CRMs): BACE2,FAM3B,UMODL1,TMPRSS2,C2CD2,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000184012, ENSG00000141956, ENSG00000157617, ENSG00000177398,

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Deatailed information for cohesin site CDBP00420140