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Basic information

CohesinDB ID: CDBP00420147

Locus: chr21-41804360-41804854

Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015

Cell type: RPE, Fibroblast, HCT-116, RT-112, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.944

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 76%, "4_Tx": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, ZNF621, FOXA1, SUZ12, ZFHX2, ZBTB7B, HDGF, ATF3, BMI1, ZNF444, TP63, ESR1, OCA2, USF2, ZIK1, CTCF, JUN, E4F1, GLI4, ZNF512B, TFAP2C, YBX1, POU2F2, CHD8, MYCN, POU5F1, ZNF239, ZBTB48, ZSCAN5A, NONO, ERG2, MYC, RFX1, GRHL3, DNMT3B, DACH1, ZNF639, NR3C1, CREB1, GRHL2, HES1, HDAC2, SSRP1, GATAD2B, NCOA2, RUNX1, SMC1A, HDAC1, ZNF707, CRY1, ZFX, TET2, ERG3, CREBBP, ZNF169, GR, NFIB, FOS, HNRNPLL, SALL1, AATF, SMC3, MLLT1, STAG1, TRP47, CBFA2T2, FOXA2, ZNF207, WT1, ZNF662, HOXB13, ZKSCAN1, RELA, ZNF148, SP140, GATA3, ZNF311, NRIP1, AGO2, KLF4, NCOA3, ZNF544, NR2F1, ZNF791, ZNF837, ZSCAN22, EGR2, AR, HEXIM1, EGR1, HSF1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): UBASH3A,RSPH1,BACE2,SLC37A1,PRDM15,FAM3B,UMODL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 68

Number of somatic mutations (non-coding): 17

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000141956, ENSG00000177398, ENSG00000160185, ENSG00000160188, ENSG00000160190,

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Deatailed information for cohesin site CDBP00420147