- Basic information
- CohesinDB ID: CDBP00420149
- Locus: chr21-41805853-41806997
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Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE98367, GSE110061, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, ENCSR703TNG, GSE25021
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, Monocytes, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 92%,
"8_ZNF/Rpts": 4%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZNF621, FOXA1, SUZ12, ZFHX2, ZBTB7B, HDGF, ATF3, BMI1, ZNF444, TP63, ESR1, OCA2, USF2, ZIK1, CTCF, JUN, E4F1, GLI4, ZNF512B, TFAP2C, YBX1, POU2F2, CHD8, MYCN, POU5F1, ZNF239, ZBTB48, ZSCAN5A, NONO, ERG2, MYC, RFX1, GRHL3, DNMT3B, DACH1, ZNF639, NR3C1, CREB1, GRHL2, HES1, HDAC2, SSRP1, GATAD2B, NCOA2, RUNX1, SMC1A, HDAC1, ZNF707, CRY1, ZFX, TET2, ERG3, CREBBP, ZNF169, GR, NFIB, FOS, HNRNPLL, SALL1, AATF, SMC3, MLLT1, STAG1, TRP47, CBFA2T2, FOXA2, ZNF207, WT1, ZNF662, HOXB13, ZKSCAN1, RELA, ZNF148, SP140, GATA3, ZNF311, NRIP1, AGO2, KLF4, NCOA3, ZNF544, NR2F1, ZNF791, ZNF837, ZSCAN22, EGR2, AR, HEXIM1, EGR1, HSF1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): UMODL1,SLC37A1,FAM3B,PRDM15,RSPH1,UBASH3A,BACE2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 176
- Number of somatic mutations (non-coding): 44
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000141956,
ENSG00000177398,
ENSG00000160185,
ENSG00000160188,
ENSG00000160190,
- Related loop:
chr21:41275000-41300000~~chr21:41800000-41825000,
chr21:41300000-41325000~~chr21:41800000-41825000,
chr21:41600000-41625000~~chr21:41800000-41825000,
chr21:41800000-41825000~~chr21:42100000-42125000,
chr21:41800000-41825000~~chr21:42425000-42450000,
chr21:41800000-41825000~~chr21:42475000-42500000,
chr21:41800000-41825000~~chr21:42500000-42525000,
chr21:41800000-41825000~~chr21:42800000-42825000,
chr21:41802187-41803544~~chr21:42125243-42126817,