- Basic information
- CohesinDB ID: CDBP00420150
- Locus: chr21-41807830-41808572
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Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191
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Cell type: RPE, Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 67%,
"4_Tx": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, ZNF621, XBP1, FOXA1, SUZ12, ZBTB7B, HDGF, BMI1, ATF3, THAP1, ZBTB5, ZNF444, CBFB, TP63, ELF1, BCLAF1, ESR1, OCA2, CTCF, TCF12, E4F1, MNT, ZNF157, PAX8, DPF2, ZNF512B, ZNF776, ZNF528, PLRG1, EHMT2, YBX1, POU2F2, CHD8, ZSCAN5D, ZNF239, ZNF263, MYCN, RUNX1T1, POU5F1, CTBP1, ZBTB1, ZBTB48, DUX4, ZSCAN5A, NONO, DDX5, PHB2, ERG, OGG1, MYC, RFX1, GRHL3, FOXK2, ZNF8, STAT3, DNMT3B, ZNF639, NR3C1, ESRRA, CEBPB, CREB1, YBX3, ARHGAP35, GABPB1, ZHX2, HES1, HDAC2, SSRP1, GATAD2B, FLI1, SALL2, PTBP1, RUNX1, HDAC1, SIRT6, ZNF707, ZFX, TET2, NFXL1, NFIB, ARNT, HMBOX1, NCAPH2, FOS, SUPT5H, CDK8, CHD1, ZNF670, ZNF680, KLF9, SREBF2, RBM22, SP1, BCL11A, ATF7, BCOR, SALL1, AATF, SMC3, MLLT1, STAG1, TRP47, ZNF207, MTA3, FOXA2, GTF2B, WT1, ZBTB33, CDK9, ZKSCAN1, YY1, RELA, TARDBP, NEUROD1, ZNF148, ZNF521, SP140, HIF1A, ZNF311, TAL1, ZNF143, AGO2, ZNF592, NCOA3, ZNF791, NR2F1, KDM5B, TP53, PKNOX1, ZSCAN22, AR, ZBTB40, RXR, HEXIM1, TFIIIC, HSF1, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PRDM15,BACE2,UBASH3A,RSPH1,FAM3B,SLC37A1,UMODL1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 16
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000141956,
ENSG00000177398,
ENSG00000160185,
ENSG00000160188,
ENSG00000160190,
- Related loop:
chr21:41275000-41300000~~chr21:41800000-41825000,
chr21:41300000-41325000~~chr21:41800000-41825000,
chr21:41600000-41625000~~chr21:41800000-41825000,
chr21:41800000-41825000~~chr21:42100000-42125000,
chr21:41800000-41825000~~chr21:42425000-42450000,
chr21:41800000-41825000~~chr21:42475000-42500000,
chr21:41800000-41825000~~chr21:42500000-42525000,
chr21:41800000-41825000~~chr21:42800000-42825000,
chr21:41802187-41803544~~chr21:42125243-42126817,