- Basic information
- CohesinDB ID: CDBP00420153
- Locus: chr21-41812630-41814016
-
Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, GSE165895
-
Cell type: RPE, Fibroblast, HCT-116, RT-112, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 54%,
"4_Tx": 42%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, TRP47, MYCN, NFATC1, ZFX, ZBTB48, WT1, FOXA1, TET2, ERG3, RELA, ZNF341, ATF3, MYC, SP140, ARNT, MECOM, STAT3, TP63, NRIP1, DNMT3B, KDM5B, TP53, PKNOX1, ESR1, ZNF334, CTCF, RBM22, AR, ZNF479, FLI1, HSF1, BRD4, MAZ, AATF, STAG1
- Target gene symbol (double-evidenced CRMs): RSPH1,SLC37A1,FAM3B,UMODL1,PRDM15,BACE2,UBASH3A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 3
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000141956,
ENSG00000177398,
ENSG00000160185,
ENSG00000160188,
ENSG00000160190,
- Related loop:
chr21:41275000-41300000~~chr21:41800000-41825000,
chr21:41281909-41284412~~chr21:41816016-41818176,
chr21:41282093-41284330~~chr21:41815923-41818297,
chr21:41282193-41284644~~chr21:41815835-41818294,
chr21:41282205-41284637~~chr21:41815737-41818351,
chr21:41282224-41284707~~chr21:41815737-41818316,
chr21:41282271-41284327~~chr21:41815837-41818350,
chr21:41282272-41284702~~chr21:41815747-41818270,
chr21:41282441-41284676~~chr21:41815802-41818289,
chr21:41282503-41284621~~chr21:41815822-41818125,
chr21:41282688-41284172~~chr21:41816062-41818083,
chr21:41300000-41325000~~chr21:41800000-41825000,
chr21:41600000-41625000~~chr21:41800000-41825000,
chr21:41609719-41611366~~chr21:41815837-41818350,
chr21:41609762-41611341~~chr21:41815868-41818188,
chr21:41609802-41611271~~chr21:41815835-41818259,
chr21:41609846-41611318~~chr21:41815737-41818351,
chr21:41609880-41611334~~chr21:41815828-41818342,
chr21:41609888-41611281~~chr21:41815812-41818317,
chr21:41609918-41611406~~chr21:41815864-41818241,
chr21:41609924-41613852~~chr21:41815772-41818348,
chr21:41609930-41611263~~chr21:41815839-41818255,
chr21:41609937-41611206~~chr21:41815911-41818342,
chr21:41609940-41611371~~chr21:41815790-41818726,
chr21:41609941-41611279~~chr21:41815811-41818198,
chr21:41609947-41611362~~chr21:41815821-41818177,
chr21:41611316-41613965~~chr21:41815851-41818361,
chr21:41611361-41613736~~chr21:41815847-41818243,
chr21:41611373-41613994~~chr21:41815828-41818342,
chr21:41611386-41613766~~chr21:41815816-41818179,
chr21:41611455-41613750~~chr21:41815821-41818177,
chr21:41611455-41613992~~chr21:41815837-41818350,
chr21:41611457-41614038~~chr21:41815831-41818342,
chr21:41611484-41613992~~chr21:41815911-41818342,
chr21:41611486-41613958~~chr21:41815790-41818726,
chr21:41611491-41613751~~chr21:41815835-41818259,
chr21:41611517-41613753~~chr21:41815741-41818325,
chr21:41611527-41614046~~chr21:41815096-41818336,
chr21:41611554-41613773~~chr21:41815864-41818241,
chr21:41611555-41613782~~chr21:41815811-41818198,
chr21:41611561-41614052~~chr21:41815802-41818289,
chr21:41611562-41613730~~chr21:41815809-41818325,
chr21:41611565-41613926~~chr21:41815814-41818320,
chr21:41611575-41614001~~chr21:41815800-41818285,
chr21:41611576-41614069~~chr21:41815809-41818141,
chr21:41611599-41613731~~chr21:41815787-41818293,
chr21:41611600-41614022~~chr21:41815737-41818351,
chr21:41611601-41613745~~chr21:41815797-41818318,
chr21:41611601-41613764~~chr21:41815824-41818136,
chr21:41611602-41613913~~chr21:41815835-41818294,
chr21:41611606-41613722~~chr21:41815780-41818270,
chr21:41611608-41614023~~chr21:41815839-41818255,
chr21:41611609-41613772~~chr21:41815812-41818317,
chr21:41611609-41614021~~chr21:41815809-41818765,
chr21:41611632-41613892~~chr21:41815997-41818148,
chr21:41611633-41613763~~chr21:41815801-41818255,
chr21:41611640-41613671~~chr21:41815868-41818188,
chr21:41611641-41613677~~chr21:41815910-41818235,
chr21:41611641-41614038~~chr21:41815999-41818227,
chr21:41611649-41613707~~chr21:41815737-41818316,
chr21:41611799-41613721~~chr21:41815785-41818093,
chr21:41611839-41613562~~chr21:41816062-41818083,
chr21:41800000-41825000~~chr21:42100000-42125000,
chr21:41800000-41825000~~chr21:42425000-42450000,
chr21:41800000-41825000~~chr21:42475000-42500000,
chr21:41800000-41825000~~chr21:42500000-42525000,
chr21:41800000-41825000~~chr21:42800000-42825000,
chr21:41815096-41818336~~chr21:42116276-42118975,
chr21:41815195-41818114~~chr21:42116443-42118958,
chr21:41815385-41818123~~chr21:42106891-42109246,
chr21:41815385-41818123~~chr21:42116645-42118612,
chr21:41815447-41818293~~chr21:42106952-42108805,
chr21:41815722-41818125~~chr21:41916406-41918311,
chr21:41815737-41818316~~chr21:41861143-41864113,
chr21:41815737-41818316~~chr21:41895209-41897144,
chr21:41815737-41818316~~chr21:42094326-42095544,
chr21:41815737-41818316~~chr21:42107070-42109056,
chr21:41815737-41818316~~chr21:42116480-42118891,
chr21:41815737-41818351~~chr21:42116256-42118602,
chr21:41815741-41818325~~chr21:41876469-41879286,
chr21:41815741-41818325~~chr21:41894768-41897068,
chr21:41815741-41818325~~chr21:41916134-41918303,
chr21:41815747-41818270~~chr21:42116587-42119641,
chr21:41815762-41818291~~chr21:42106954-42108828,
chr21:41815762-41818291~~chr21:42116742-42118600,
chr21:41815772-41818348~~chr21:41861159-41863293,
chr21:41815772-41818348~~chr21:41916377-41918020,
chr21:41815785-41818093~~chr21:42106648-42108930,
chr21:41815785-41818093~~chr21:42116635-42118386,
chr21:41815787-41818293~~chr21:41916417-41918064,
chr21:41815787-41818293~~chr21:41931609-41933343,
chr21:41815790-41818726~~chr21:42116679-42118765,
chr21:41815797-41818318~~chr21:42116717-42118997,
chr21:41815801-41818255~~chr21:42116652-42118623,
chr21:41815802-41818289~~chr21:42116718-42118814,
chr21:41815809-41818325~~chr21:42116692-42118897,
chr21:41815809-41818765~~chr21:42116737-42118378,
chr21:41815822-41818125~~chr21:42116708-42118554,
chr21:41815837-41818350~~chr21:42116767-42118662,
chr21:41815837-41818350~~chr21:42125269-42126883,
chr21:41815839-41818255~~chr21:42116749-42118385,
chr21:41815923-41818297~~chr21:42106594-42109053,
chr21:41815923-41818297~~chr21:42116811-42119739,
chr21:41816016-41818176~~chr21:42116818-42119705,
chr21:41816044-41818153~~chr21:42116850-42119542,
chr21:41816062-41818083~~chr21:42107290-42108688,
chr21:41816081-41818131~~chr21:42116778-42118373,
chr21:41816104-41818123~~chr21:41861421-41862854,