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Basic information

CohesinDB ID: CDBP00420154

Locus: chr21-41814372-41823630

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 83% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.111

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 51%, "4_Tx": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, TRIM25, FOSL1, PGR, SMARCA2, ZNF660, XBP1, PATZ1, FOXA1, RXRB, PBX2, KDM3A, TFAP4, SIN3B, ATF3, THAP1, CTCFL, CBFB, MXD4, MECOM, PAX5, TP63, JMJD1C, TEAD1, TRIM28, ELF1, RBM39, BCLAF1, SNAI2, NFE2L2, LMO2, ESR1, KLF6, RCOR2, JUN, CTCF, TCF12, BAF155, KLF1, LMO1, GATA6, SOX5, SIX5, IRF4, E2F4, E2F1, SMC1, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, EED, TFAP2C, GLIS1, JARID2, PDX1, NANOG, POU2F2, ZSCAN5D, MYCN, ZNF263, POU5F1, ID3, ZSCAN21, ZBTB48, ZSCAN5A, STAT1, SRF, GATAD1, SAP130, ERG2, ERG, HOXC5, ASCL1, OGG1, MYC, SMARCA4, ZNF2, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, PROX1, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, PRDM14, RCOR1, DNMT3B, NR2F6, NFE2, MIER3, HNRNPH1, NR3C1, CEBPB, CREB1, EZH2, JMJD6, GABPB1, ZHX2, SPI1, MIXL1, TFE3, IRF1, HDAC2, GATA2, MXD3, FLI1, DRAP1, ZGPAT, RELB, MRTFB, NFIL3, ATF1, PTBP1, ETV5, RUNX1, THAP11, SMC1A, BCL6, CEBPA, SIRT6, NKX2-2, CBX1, SOX13, ZFX, AFF4, ZNF534, SMAD3, ZNF654, ERG3, TRIM22, TWIST1, SMARCC1, PRDM10, MEF2A, CREBBP, ZBTB2, NOTCH1, ZNF35, TAF15, RARA, RUNX2, ZNF384, ZNF184, ARNT, PBX4, ZNF48, SMAD4, HMBOX1, NCAPH2, FOS, CDK8, HMGXB4, CHD1, MED1, ZEB1, TEAD3, KDM6B, MYB, PIAS1, SMAD1, ZNF331, ZNF3, KLF16, RBM22, MAFK, SP1, BCL11A, HNF4A, ARID2, REST, IKZF5, ZBTB7A, ZSCAN31, ATF7, ZHX1, ASH2L, HNRNPLL, TCF3, FOXP1, AATF, SMC3, ELL2, STAG1, MLLT1, STAG2, TRP47, CBFA2T2, KLF13, SAFB, FOXA2, AGO1, MTA3, CREM, EBF1, CBX3, MIER2, GTF2B, WT1, ZBTB33, CDK9, ZNF580, ZKSCAN1, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, SP140, TCF4, HIF1A, ZFP36, SKIL, BHLHE22, GATA3, BATF, TAL1, MAX, ZNF143, AGO2, KLF4, BCL11B, SP7, NCOA3, GFI1B, CEBPG, NR2F2, NR2F1, KDM5B, TP53, NFKB1, MYOD1, ELF3, PHF5A, KAT8, BRD2, BHLHE40, AR, ARID4B, NFKBIZ, RXR, ZNF324, EGLN2, ZBTB42, HEXIM1, RB1, TFIIIC, HSF1, ZBTB26, SCRT1, BRD4, ILF3, CUX1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): UBASH3A,UMODL1,PRDM15,BACE2,RSPH1,C2CD2,FAM3B,SLC37A1

Function elements

Human SNPs: ADAMTS13_levels

Number of somatic mutations (coding): 952

Number of somatic mutations (non-coding): 238

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160185, ENSG00000160188, ENSG00000160190,

eachgene

Deatailed information for cohesin site CDBP00420154