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Basic information

CohesinDB ID: CDBP00420156

Locus: chr21-41827924-41829367

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE110061, GSE116868, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE25021

Cell type: MCF-7, RPE, Fibroblast, HCT-116, MB157, RT-112, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: non-Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 52%, "4_Tx": 40%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, ZBTB7B, HDGF, THAP1, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, HDAC8, E4F1, ZNF157, PYGO2, PAX8, ZNF407, E2F4, ZNF410, ZNF528, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ZMYND11, ERG, EZH1, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, RCOR1, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, KLF17, GATA2, ZNF644, FLI1, HCFC1, ZNF785, RELB, HCFC1R1, EP400, RUNX1, HDAC1, CEBPA, ZNF707, CRY1, TET2, MCM2, SMARCC1, ZBTB2, SNIP1, ATF2, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, C11orf30, STAT5A, ARID2, RBM25, AFF1, MBD2, ZNF704, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, PAF1, WT1, MEF2C, NEUROD1, ZFP36, TCF4, BATF, PLAG1, KLF4, ZNF544, MED, EGR2, RBM14, ELF3, RXR, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ADNP, ZNF316, ZNF621, XBP1, KDM4B, PBX2, ATF3, RUNX3, CBFB, ZSCAN4, TP63, CDC5L, ZNF467, MAF, ELF1, SNAI2, ZIK1, CTCF, JUN, MNT, ZBTB20, DPF2, IRF4, DDX20, ZNF280A, PLRG1, TFAP2C, RBPJ, YBX1, ZNF239, MTA2, ZSCAN21, ZBTB48, ZNF317, NONO, SRF, DDX5, NBN, PHB2, CHD4, PBX1, TRIP13, ZNF2, PRDM14, LEF1, TERF2, NR3C1, ESRRA, KMT2A, CCAR2, ZNF560, KLF8, ARHGAP35, GRHL2, ZNF292, SSRP1, ZNF146, ZSCAN29, SMARCA5, CC2D1A, SOX13, ZNF18, ARNT, NFIB, PRDM9, ZEB2, PBX3, NCAPH2, TEAD3, DIDO1, ZNF670, ZNF680, TBX5, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, SMC3, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, ZKSCAN1, KDM1A, ZNF266, ZNF155, ZIC2, GATA3, TAL1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, NFKB1, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, ZSCAN23, IRF9, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, BMI1, CHD7, ZNF444, ATF4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ASH1L, ZSCAN5A, HIC1, SP4, ERG2, TBP, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, PHF8, SPI1, PCBP1, HDAC2, GATAD2B, SALL2, BCL6, ERG3, NFXL1, MEF2A, MYBL2, CREBBP, ZNF35, ZNF384, ZNF133, CDK8, ZEB1, ZMYM3, NCOA1, RBM22, MAFK, NR4A1, ZNF799, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, HDAC6, GTF2B, ZNF662, ZNF318, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, GFI1B, ZNF791, NR2F1, KDM5B, PKNOX1, MYOD1, T, AR, ZNF324, HEXIM1, AHR, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF274, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, THRAP3, KLF5, BCLAF1, TRIM28, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, GLI4, RAD51, ZNF512B, SMC1, TEAD4, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, ID3, ARID3A, ZNF300, ZNF585B, ASCL1, MIER1, RAD21, GRHL3, APC, XRCC5, ZNF639, ZNF750, HES1, IRF1, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZFX, SMAD3, IRF2, BRD9, RUNX2, GATA4, OSR2, ZNF184, FOS, SUPT5H, MED1, KDM6B, ZNF558, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, PHF20, ZBTB7A, CCNT2, POU2F3, SALL1, TCF3, ZNF283, NCOA4, KLF13, FOXA2, RBBP5, E2F8, ZNF600, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, SP140, HIF1A, ZNF449, GATA1, TLE3, NCOA3, ZNF687, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): RIPK4,BACE2,TMPRSS2,PRDM15,UBASH3A,FAM3B,ABCG1,MX1,UMODL1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 144

Number of somatic mutations (non-coding): 30

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160179, ENSG00000160185,

eachgene

Deatailed information for cohesin site CDBP00420156