Deatailed information for cohesin site CDBP00420160

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00420160
  • Locus: chr21-41842489-41843082
  • Data sourse: GSE67783, GSE111913, ENCSR153HNT
  • Cell type: K-562, RT-112, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.967
  • Subunit: SA1,SMC1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: non-Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 96% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 91%, "15_Quies": 7%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, ZBTB7B, HDGF, THAP1, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, HDAC8, E4F1, ZNF157, PYGO2, PAX8, ZNF407, E2F4, ZNF410, ZNF528, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ZMYND11, ERG, EZH1, SMARCA4, RFX1, DNMT1, FOXK2, ZNF8, RCOR1, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, KLF17, GATA2, ZNF644, FLI1, HCFC1, ZNF785, RELB, HCFC1R1, EP400, RUNX1, HDAC1, CEBPA, ZNF707, CRY1, TET2, MCM2, SMARCC1, ZBTB2, SNIP1, ATF2, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, C11orf30, STAT5A, ARID2, RBM25, AFF1, MBD2, ZNF704, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, PAF1, WT1, MEF2C, NEUROD1, ZFP36, TCF4, BATF, PLAG1, KLF4, ZNF544, MED, EGR2, RBM14, ELF3, RXR, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ADNP, ZNF316, ZNF621, XBP1, KDM4B, PBX2, ATF3, RUNX3, CBFB, ZSCAN4, TP63, CDC5L, ZNF467, MAF, ELF1, SNAI2, ZIK1, CTCF, JUN, MNT, ZBTB20, DPF2, IRF4, DDX20, ZNF280A, PLRG1, TFAP2C, RBPJ, YBX1, ZNF239, MTA2, ZSCAN21, ZBTB48, ZNF317, NONO, SRF, DDX5, NBN, PHB2, CHD4, PBX1, TRIP13, ZNF2, PRDM14, LEF1, TERF2, NR3C1, ESRRA, KMT2A, CCAR2, ZNF560, KLF8, ARHGAP35, GRHL2, ZNF292, SSRP1, ZNF146, ZSCAN29, SMARCA5, CC2D1A, SOX13, ZNF18, ARNT, NFIB, PRDM9, ZEB2, PBX3, NCAPH2, TEAD3, DIDO1, ZNF670, ZNF680, TBX5, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, SMC3, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, ZKSCAN1, KDM1A, ZNF266, ZNF155, ZIC2, GATA3, TAL1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, NFKB1, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, ZSCAN23, IRF9, PGR, CBX5, SOX2, PATZ1, LEO1, UBTF, BMI1, CHD7, ZNF444, ATF4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, E2F6, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ASH1L, ZSCAN5A, HIC1, SP4, ERG2, TBP, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, PHF8, SPI1, PCBP1, HDAC2, GATAD2B, SALL2, BCL6, ERG3, NFXL1, MEF2A, MYBL2, CREBBP, ZNF35, ZNF384, ZNF133, CDK8, ZEB1, ZMYM3, NCOA1, RBM22, MAFK, NR4A1, ZNF799, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, HDAC6, GTF2B, ZNF662, ZNF318, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, GFI1B, ZNF791, NR2F1, KDM5B, PKNOX1, MYOD1, T, AR, ZNF324, HEXIM1, AHR, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF274, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, THRAP3, KLF5, BCLAF1, TRIM28, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, GLI4, RAD51, ZNF512B, SMC1, TEAD4, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, ID3, ARID3A, ZNF300, ZNF585B, ASCL1, MIER1, RAD21, GRHL3, APC, XRCC5, ZNF639, ZNF750, HES1, IRF1, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZFX, SMAD3, IRF2, BRD9, RUNX2, GATA4, OSR2, ZNF184, FOS, SUPT5H, MED1, KDM6B, ZNF558, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, PHF20, ZBTB7A, CCNT2, POU2F3, SALL1, TCF3, ZNF283, NCOA4, KLF13, FOXA2, RBBP5, E2F8, ZNF600, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, SP140, HIF1A, ZNF449, GATA1, TLE3, NCOA3, ZNF687, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): RIPK4,ABCG1,MX1,UMODL1,PRDM15,UBASH3A,BACE2,FAM3B,TMPRSS2
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 4
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157601, ENSG00000184012, ENSG00000183421, ENSG00000141956, ENSG00000177398, ENSG00000160179, ENSG00000160185,
  • Related loop: chr21:41200000-41225000~~chr21:41825000-41850000, chr21:41275000-41300000~~chr21:41825000-41850000, chr21:41300000-41325000~~chr21:41825000-41850000, chr21:41450000-41475000~~chr21:41825000-41850000, chr21:41600000-41625000~~chr21:41825000-41850000, chr21:41725000-41750000~~chr21:41825000-41850000, chr21:41825000-41850000~~chr21:42100000-42125000, chr21:41825000-41850000~~chr21:42275000-42300000, chr21:41825000-41850000~~chr21:42425000-42450000, chr21:41846872-41848292~~chr21:42116256-42118602,
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