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Basic information

CohesinDB ID: CDBP00420164

Locus: chr21-41852110-41853345

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 49%, "5_TxWk": 44%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: XBP1, FOXA1, ZFHX2, HNRNPK, ATF3, CBFB, MITF, TEAD1, SNAI2, ESR1, OCA2, CTCF, MNT, TEAD4, TFAP2C, CDK9-HEXIM1, CHD8, BRD1, POU2F2, MYCN, POU5F1, TOP2A, ZMYND11, ZBTB48, ZSCAN5A, STAT1, ERG2, ERG, OGG1, MYC, RAD21, GRHL3, STAT3, DNMT3B, ZNF750, SRSF3, BMPR1A, GRHL2, SPI1, GATA2, FLI1, RUNX1, SMC1A, SIRT6, ZFX, SMAD3, PCBP2, TET2, ERG3, IRF2, CREBBP, ARNT, PRDM9, FOS, KDM6B, SCRT2, SETDB1, RBM22, REST, POU2F3, AATF, SMC3, STAG1, TRP47, TBL1X, FOXA2, ZSCAN16, WT1, HOXB13, YY1, RELA, TARDBP, SP140, TCF4, ZIC2, ZFP36, HIF1A, TAL1, ZNF143, AGO2, NR2F1, KDM5B, ZNF334, EGR2, AR, RXR, HEXIM1, HSF1, ZBTB26, SCRT1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): C2CD2,MX2,ABCG1,FAM3B,UMODL1,RIPK4,PRDM15

Function elements

Human SNPs: .

Number of somatic mutations (coding): 12

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000183844, ENSG00000183486, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420164