- Basic information
- CohesinDB ID: CDBP00420165
- Locus: chr21-41853692-41855866
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Data sourse: GSE67783, GSE72082, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE68388, ENCSR703TNG, GSE25021, GSE50893
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, SNYDER, RT-112, K-562, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.900
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 60%,
"5_TxWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: XBP1, FOXA1, ZFHX2, HNRNPK, ATF3, CBFB, MITF, TEAD1, SNAI2, ESR1, OCA2, CTCF, MNT, TEAD4, TFAP2C, CDK9-HEXIM1, CHD8, BRD1, POU2F2, MYCN, POU5F1, TOP2A, ZMYND11, ZBTB48, ZSCAN5A, STAT1, ERG2, ERG, OGG1, MYC, RAD21, GRHL3, STAT3, DNMT3B, ZNF750, SRSF3, BMPR1A, GRHL2, SPI1, GATA2, FLI1, RUNX1, SMC1A, SIRT6, ZFX, SMAD3, PCBP2, TET2, ERG3, IRF2, CREBBP, ARNT, PRDM9, FOS, KDM6B, SCRT2, SETDB1, RBM22, REST, POU2F3, AATF, SMC3, STAG1, TRP47, TBL1X, FOXA2, ZSCAN16, WT1, HOXB13, YY1, RELA, TARDBP, SP140, TCF4, ZIC2, ZFP36, HIF1A, TAL1, ZNF143, AGO2, NR2F1, KDM5B, ZNF334, EGR2, AR, RXR, HEXIM1, HSF1, ZBTB26, SCRT1, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): FAM3B,MX2,UMODL1,ABCG1,RIPK4,PRDM15,C2CD2
- Function elements
- Human SNPs: Response_to_taxane_treatment_(placlitaxel)
- Number of somatic mutations (coding): 252
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000183844,
ENSG00000183486,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:41200000-41225000~~chr21:41825000-41850000,
chr21:41275000-41300000~~chr21:41825000-41850000,
chr21:41300000-41325000~~chr21:41825000-41850000,
chr21:41350000-41375000~~chr21:41850000-41875000,
chr21:41450000-41475000~~chr21:41825000-41850000,
chr21:41600000-41625000~~chr21:41825000-41850000,
chr21:41600000-41625000~~chr21:41850000-41875000,
chr21:41725000-41750000~~chr21:41825000-41850000,
chr21:41750000-41775000~~chr21:41850000-41875000,
chr21:41825000-41850000~~chr21:42100000-42125000,
chr21:41825000-41850000~~chr21:42275000-42300000,
chr21:41825000-41850000~~chr21:42425000-42450000,
chr21:41850000-41875000~~chr21:41950000-41975000,
chr21:41850000-41875000~~chr21:42050000-42075000,
chr21:41850000-41875000~~chr21:42075000-42100000,
chr21:41850000-41875000~~chr21:42100000-42125000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:41850000-41875000~~chr21:42275000-42300000,