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Basic information

CohesinDB ID: CDBP00420166

Locus: chr21-41857229-41860002

Data sourse: ENCSR000BLD, GSE104888, GSE72082, GSE116868, GSE105028, GSE25021, GSE131606, GSE115602, ENCSR000BTU, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, ENCSR000BLS, GSE206145, ENCSR000BTQ, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE50893, GSE38411

Cell type: MCF-7, GM18526, H1-hESC, Fibroblast, GM19239, HCT-116, Hep-G2, MB157, RPE, Ishikawa, RT-112, H9-hESC, K-562, BCBL-1, HSPC, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.811

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 52%, "5_TxWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, GLIS1, TRP47, NANOG, BCL6, SMC1A, FOXA2, CEBPA, ZNF263, MYCN, RUNX1T1, ZFX, SIRT6, XBP1, ZBTB48, PCBP2, ZSCAN5A, FOXA1, WT1, STAT1, TET2, DDX5, CDK9, HOXB13, HNRNPK, ZNF19, YY1, CREBBP, ERG, RELA, OGG1, ATF3, RUNX2, AHR, MYC, THAP1, RAD21, SP140, GRHL3, HIF1A, CBFB, STAT3, ZNF143, AGO2, FOS, DNMT3B, SMARCB1, CHD1, CEBPG, CEBPB, NR3C1, KDM6B, TRIM28, SCRT2, SNAI2, NR2F1, KDM5B, ESR1, TP53, KLF9, ZNF334, ZNF140, CTCF, RBM22, BCL11A, HNF4A, FOSL1, KLF17, AR, PCBP1, RXR, HEXIM1, HSF1, HNRNPLL, BRD4, SCRT1, TCF3, MAZ, SMC1, AATF, HCFC1R1, STAG1, TFAP2C

Target gene symbol (double-evidenced CRMs): RIPK4,PRDM15,UMODL1,FAM3B,MX2,C2CD2,ABCG1

Function elements

Human SNPs: Deep_white_matter_hyperintensities

Number of somatic mutations (coding): 424

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000183844, ENSG00000183486, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420166