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Basic information

CohesinDB ID: CDBP00420167

Locus: chr21-41861355-41866024

Data sourse: ENCSR000BLD, GSE72082, ENCSR501LQA, GSE105028, GSE131606, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE93080, GSE206145-NatGen2015, GSE138105, ENCSR199XBQ, ENCSR000EEG, ENCSR338DUC, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR981FDC, GSE62063, GSE97394, ENCSR217ELF, GSE55407, ENCSR167MTG, ENCSR853VWZ, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE50893, ENCSR748MVX

Cell type: GM10847, GM2610, SLK, HSPC, Liver, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, Ishikawa, GM12890, IMR-90, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, GM18505, GM12878, GM12891, GM2588, RT-112, GM19193, THP-1, GM19099, HUES64, Ramos, GM12892, HCT-116, Hep-G2, A-549, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 20% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.611

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 60%, "7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, E2F7, MEIS2, XBP1, PATZ1, FOXA1, SUZ12, RBFOX2, PBX2, UBTF, ZFHX2, HDGF, ATF3, NFIC, ZFP64, THAP1, RUNX3, CBFB, DPF1, SMARCE1, PAX5, MITF, BACH2, KLF5, ELF1, BCLAF1, TRIM28, TEAD1, RBM39, NFE2L2, LMO2, ESR1, ZNF217, RCOR2, OCA2, USF2, CTCF, ZNF577, TCF12, JUN, KLF1, BAF155, ZBTB20, MNT, SOX5, E4F1, DPF2, PAX8, GATA6, E2F6, IRF4, TRIM24, ZNF407, RAD51, ZNF512B, E2F1, FOXA3, PDX1, TFAP2C, EED, RBPJ, GLIS1, YBX1, EHMT2, POU2F2, ZNF263, MYCN, ID3, CTBP1, MTA2, ZBTB17, ZBTB48, STAT1, SRF, SAP130, NBN, ERG2, ARID3A, TBP, ERG, CHD4, MIER1, ZNF597, ZNF341, MYC, SMARCA4, ARID1B, RAD21, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, PRDM14, IKZF1, RCOR1, DNMT3B, LEF1, NR3C1, CEBPB, SRSF3, KMT2A, ZBTB11, CREB1, EZH2, ARHGAP35, FEZF1, GABPB1, ELF4, SPI1, ZNF257, PCBP1, HDAC2, GATA2, GATAD2B, MXD3, FLI1, HCFC1, MXI1, SMARCA5, RELB, MRTFB, ZNF554, ZNF316, ATF1, ETV5, CC2D1A, RUNX1, BCL6, SMC1A, CEBPA, CBX1, NKX2-2, HDAC1, SIN3A, ZFX, ZNF335, SMAD3, ZNF770, ERG3, TET2, NFXL1, TRIM22, PRDM10, NSD2, MEF2A, CREBBP, ZBTB2, ZNF384, BRD9, RUNX2, ZNF184, ARNT, BACH1, ZNF48, ATF2, ZEB2, ETV6, FOXM1, FOS, SNRNP70, EP300, MED1, ZEB1, TEAD3, MYB, SCRT2, PIAS1, ZMYM3, C11orf30, L3MBTL2, SETDB1, RBM22, USF1, SP1, BCL11A, MAFK, HNF4A, NIPBL, ZBTB7A, ATF7, ASH2L, HNRNPLL, TCF3, BCOR, FOXP1, AATF, SMC3, ELL2, NCOR2, STAG1, MLLT1, NFATC3, TRP47, CBFA2T2, MEF2B, KLF13, FOXA2, MTA3, EBF1, RBBP5, ZNF207, CREM, ZNF600, ZSCAN16, GTF2B, WT1, E2F8, ZBED1, CHD2, ZBTB33, CDK9, HOXB13, ZKSCAN1, BCL3, KDM1A, YY1, RELA, TARDBP, NEUROD1, JUNB, SP140, ZFP36, HIF1A, SKIL, GATA3, ZNF311, BATF, TAL1, MAX, ZNF740, SPIB, ZNF143, AGO2, GATA1, NRIP1, MTA1, PLAG1, CEBPG, ZNF592, NR2F1, ZNF687, TP53, PKNOX1, ZNF334, NFKB1, EGR2, TBX21, BHLHE40, AR, ARID4B, TAF1, ZBTB40, EGR1, RB1, HSF1, NCOR1, IKZF2, BRD4, RNF2, SCRT1, JUND, ILF3, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): UMODL1,C2CD2,FAM3B,PRDM15,RIPK4,MX2,ABCG1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 255

Number of somatic mutations (non-coding): 85

Related genes and loops

Related gene: ENSG00000183844, ENSG00000183486, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179,

eachgene

Deatailed information for cohesin site CDBP00420167