- Basic information
- CohesinDB ID: CDBP00420168
- Locus: chr21-41866387-41867228
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Data sourse: GSE206145, GSE67783, GSE86191
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Cell type: RPE, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SA1,Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 67%,
"15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, SOX2, XBP1, FOXA1, LEO1, HNRNPK, TFAP4, HDGF, ATF3, NFIC, RUNX3, CBFB, PAX5, BACH2, JMJD1C, ZNF121, BCLAF1, RBM39, ZNF217, LMO2, OCA2, ESR1, HDAC8, CTCF, TCF12, ZNF260, GATA6, DPF2, PAX8, IRF4, RAD51, KMT2B, RBPJ, EED, TFAP2C, POU2F2, CHD8, ZNF263, MYCN, TOP2A, MTA2, ZMYND11, ZBTB48, STAT1, NBN, ARID3A, ERG, PBX1, ZNF341, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, STAT3, APC, IKZF1, DNMT3B, HNRNPH1, NR3C1, CEBPB, KMT2A, CREB1, EBF3, SPI1, GATAD2B, FLI1, SMARCA5, RELB, MRTFB, RUNX1, BCL6, SMC1A, ZFX, SMAD3, TET2, ERG3, TRIM22, PRDM10, MEF2A, CREBBP, ZNF384, ZBTB2, ARNT, BACH1, NRF1, PBX3, ETV6, SUPT5H, MED1, ZEB1, TERF1, MYB, ZNF3, SREBF2, RBM22, MAFK, BCL11A, NIPBL, SP1, GSPT2, NR4A1, ZBTB7A, ATF7, POU2F3, ASH2L, BCOR, FOXP1, TCF3, SMC3, NCOR2, MLLT1, STAG1, NFATC3, TRP47, CBFA2T2, KLF13, MEF2B, FOXA2, MTA3, EBF1, CREM, PAF1, E2F8, GTF2B, WT1, ZBED1, ZBTB33, CDK9, KDM1A, YY1, RELA, TARDBP, JUNB, SP140, TCF4, SKIL, ZFP36, ZIC2, HIF1A, BATF, MAX, ZNF143, NCOA3, NR2F1, NEUROG2, ZNF687, PKNOX1, TBX21, BHLHE40, AR, ZBTB40, ZBTB42, RB1, HSF1, RNF2, IKZF2, BRD4, NCOR1, CUX1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): C2CD2,ABCG1,FAM3B,PRDM15,UMODL1,MX2,RIPK4
- Function elements
- Human SNPs: Insomnia
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000183844,
ENSG00000183486,
ENSG00000183421,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
- Related loop:
chr21:41350000-41375000~~chr21:41850000-41875000,
chr21:41600000-41625000~~chr21:41850000-41875000,
chr21:41750000-41775000~~chr21:41850000-41875000,
chr21:41815737-41818316~~chr21:41861143-41864113,
chr21:41815772-41818348~~chr21:41861159-41863293,
chr21:41816104-41818123~~chr21:41861421-41862854,
chr21:41832160-41834589~~chr21:41867750-41870564,
chr21:41850000-41875000~~chr21:41950000-41975000,
chr21:41850000-41875000~~chr21:42050000-42075000,
chr21:41850000-41875000~~chr21:42075000-42100000,
chr21:41850000-41875000~~chr21:42100000-42125000,
chr21:41850000-41875000~~chr21:42225000-42250000,
chr21:41850000-41875000~~chr21:42275000-42300000,