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Basic information

CohesinDB ID: CDBP00420169

Locus: chr21-41867863-41869049

Data sourse: ENCSR000DZP, GSE67783, GSE155324, GSE206145, GSE206145-NatGen2015, GSE62063, ENCSR000BMY, GSE50893, GSE165895

Cell type: GM10847, GM2610, B-cell, RPE, GM2630, Fibroblast, GM12890, GM2255, GM18486, HFFc6, GM18951, SNYDER, GM18505, Lymphoblast, GM12878, GM12891, GM2588, GM19239, GM19099, Ramos, GM12892, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.744

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 64%, "15_Quies": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SOX2, XBP1, FOXA1, LEO1, HNRNPK, TFAP4, HDGF, ATF3, NFIC, RUNX3, CBFB, PAX5, BACH2, JMJD1C, ZNF121, BCLAF1, RBM39, ZNF217, LMO2, OCA2, ESR1, HDAC8, CTCF, TCF12, ZNF260, GATA6, DPF2, PAX8, IRF4, RAD51, KMT2B, RBPJ, EED, TFAP2C, POU2F2, CHD8, ZNF263, MYCN, TOP2A, MTA2, ZMYND11, ZBTB48, STAT1, NBN, ARID3A, ERG, PBX1, ZNF341, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, STAT3, APC, IKZF1, DNMT3B, HNRNPH1, NR3C1, CEBPB, KMT2A, CREB1, EBF3, SPI1, GATAD2B, FLI1, SMARCA5, RELB, MRTFB, RUNX1, BCL6, SMC1A, ZFX, SMAD3, TET2, ERG3, TRIM22, PRDM10, MEF2A, CREBBP, ZNF384, ZBTB2, ARNT, BACH1, NRF1, PBX3, ETV6, SUPT5H, MED1, ZEB1, TERF1, MYB, ZNF3, SREBF2, RBM22, MAFK, BCL11A, NIPBL, SP1, GSPT2, NR4A1, ZBTB7A, ATF7, POU2F3, ASH2L, BCOR, FOXP1, TCF3, SMC3, NCOR2, MLLT1, STAG1, NFATC3, TRP47, CBFA2T2, KLF13, MEF2B, FOXA2, MTA3, EBF1, CREM, PAF1, E2F8, GTF2B, WT1, ZBED1, ZBTB33, CDK9, KDM1A, YY1, RELA, TARDBP, JUNB, SP140, TCF4, SKIL, ZFP36, ZIC2, HIF1A, BATF, MAX, ZNF143, NCOA3, NR2F1, NEUROG2, ZNF687, PKNOX1, TBX21, BHLHE40, AR, ZBTB40, ZBTB42, RB1, HSF1, RNF2, IKZF2, BRD4, NCOR1, CUX1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ABCG1,PRDM15,RIPK4,C2CD2,MX2,UMODL1,FAM3B

Function elements

Human SNPs: .

Number of somatic mutations (coding): 3

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000183844, ENSG00000183486, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000177398, ENSG00000160179,

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Deatailed information for cohesin site CDBP00420169