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Basic information

CohesinDB ID: CDBP00420172

Locus: chr21-41874717-41875401

Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: RPE, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 62%, "15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, THAP1, ZBTB44, MORC2, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, ARID5B, ZNF75A, SOX5, PAX8, E2F4, ZNF674, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, BRD3, POU5F1, CTBP1, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, FOXK2, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, ELK1, ZBTB10, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, ZFP36, TCF4, BATF, PLAG1, KLF4, BCL11B, ZFP69B, MED, EGR2, RBM14, ELF3, ARID4B, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, SRSF4, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, CBFB, ZSCAN4, TP63, MITF, BACH2, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, JUN, TAF3, MNT, ZBTB20, DPF2, RYBP, SIX5, IRF4, PDX1, RBPJ, TFAP2C, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, PBX1, TSHZ1, HOMEZ, ZNF2, KDM4A, FOXP2, RXRA, PRDM14, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, LDB1, SOX13, AFF4, ZNF770, ZNF513, ZMIZ1, ZNF18, SP3, ARNT, BACH1, ZNF48, ZEB2, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF441, BRG1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, MTA1, CBX2, TP53, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, TBX2, PGR, FANCL, PATZ1, LEO1, RING1B, UBTF, TFAP4, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, KLF1, SOX9, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF76, ETV5, BCL6, SIN3A, ZBTB12, ERG3, MEF2A, CREBBP, ZNF35, ZNF384, NFYC, TAF15, RARA, SMAD4, CDK8, CSNK2A1, ZEB1, ZNF264, ZMYM3, NCOA1, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, YY2, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, ZNF395, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, ZNF362, CTCFL, PRDM1, KLF14, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, ZNF641, SOX6, CREB3, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, MLLT3, GATAD1, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, HES1, ZNF664, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, ZNF45A, MAFG, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, FOS, SUPT5H, CHD1, MED1, ZNF7, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, FOXF1, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PRDM15,FAM3B,MX2,ZBTB21,C2CD2,ABCG1,UMODL1,RIPK4

Function elements

Human SNPs: .

Number of somatic mutations (coding): 12

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000183844, ENSG00000183486, ENSG00000183421, ENSG00000141956, ENSG00000157617, ENSG00000173276, ENSG00000177398, ENSG00000160179,

eachgene

Deatailed information for cohesin site CDBP00420172