- Basic information
- CohesinDB ID: CDBP00420175
- Locus: chr21-41883793-41886940
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE116868, GSE105028, GSE121355, GSE25021, GSE131606, ENCSR000EDW, GSE93080, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE129526, ENCSR153HNT, GSE83726, GSE50893
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Cell type: RH4, GM10847, GM2610, GM19240, HSPC, H9-hESC, RPE, Fibroblast, GM12890, GM2255, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, MB157, GM12878, GM12891, GM2588, GM19239, GM19193, GM19099, HUES64, Macrophage, GM12892, MCF-7, HCT-116, Hep-G2, GM19238, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.656
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 53%,
"15_Quies": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, ZSCAN5C, XBP1, FOXA1, ATF3, RUNX3, TP63, JMJD1C, RBM39, SNAI2, ESR1, OCA2, CTCF, JUN, TCF12, LMO1, IRF4, FOXA3, GATAD2A, POU2F2, CHD8, BRD1, MYCN, POU5F1, ZBTB48, ZSCAN5A, ERG, PBX1, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, GABPA, STAT3, XRCC5, IKZF1, HNRNPH1, NR3C1, CEBPB, KMT2A, CREB1, BMPR1A, ZNF652, GABPB1, SPI1, GATA2, MXD3, SIX2, FLI1, NCOA2, RUNX1, SMC1A, CEBPA, FIP1L1, ZFX, SOX13, TET2, ZNF549, ZBTB2, NOTCH1, ARNT, ZNF48, FOS, CDK8, MED1, TEAD3, KDM6B, MYB, SCRT2, NCOA1, RBM22, BCL11A, IKZF5, PHIP, TCF3, FOXP1, AATF, SMC3, STAG1, NFATC3, TRP47, FOXA2, TBL1X, PAF1, ZNF600, WT1, FOXF1, CDK9, YY1, RELA, NEUROD1, SP140, TCF4, OTX2, TAL1, AGO2, HAND2, BCL11B, ZNF334, BHLHE40, PAX3-FOXO1, ZBTB40, RXR, HSF1, ZBTB26, BRD4, SCRT1, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): C2CD2,ZBTB21,UMODL1,PRDM15
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 32
- Number of somatic mutations (non-coding): 19
- Related genes and loops
- Related gene:
ENSG00000141956,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
- Related loop:
chr21:41611484-41613992~~chr21:41877559-41880450,
chr21:41815741-41818325~~chr21:41876469-41879286,
chr21:41832160-41834589~~chr21:41876469-41879286,
chr21:41875000-41900000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:42000000-42025000,
chr21:41875000-41900000~~chr21:42100000-42125000,
chr21:41876408-41880502~~chr21:42116480-42118891,
chr21:41877545-41880451~~chr21:42008763-42011946,