- Basic information
- CohesinDB ID: CDBP00420182
- Locus: chr21-41898621-41901470
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Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE98367, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE50893, GSE126755
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Cell type: MCF-7, GM12892, GM2630, Fibroblast, HCT-116, Macrophage, RPE, GM12891, RT-112, K-562, Neutrophil, HSPC, GM18486
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 44%,
"4_Tx": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, E2F7, SOX2, MEIS2, FOXA1, SUZ12, PBX2, UBTF, ZFHX2, HDGF, LYL1, ZNF90, ATF3, NFIC, ZNF362, CHD7, RUNX3, CBFB, ZNF189, SMARCE1, TP63, MITF, JMJD1C, MAF, TEAD1, TRIM28, E2F5, RBM39, ETV1, NFE2L2, ELF1, LMO2, ESR1, HNF1B, BCLAF1, SNAI2, JUN, TCF12, CTCF, EP300, ARID5B, LMO1, MNT, DPF2, SOX4, E2F6, TRIM24, SOX6, PRKDC, E2F1, TEAD4, EHMT2, TFAP2C, PDX1, RBPJ, GLIS1, POU2F2, BRD1, ZSCAN5D, MYCN, ZNF263, RUNX1T1, CDK7, POU5F1, CTBP1, MTA2, ZBTB48, ZSCAN5A, STAT1, ZNF134, ZNF563, MLLT3, NBN, ERG2, TBP, HOXC5, ERG, PBX1, OGG1, MYC, SMARCA4, RFX1, ARID1B, RAD21, GRHL3, RXRA, FOXK2, GABPA, APC, STAT3, XRCC5, NKX3-1, IKZF1, NFE2, RCOR1, NR2F6, LEF1, DNMT3B, ZNF667, NR3C1, ESRRA, SRSF3, CEBPB, STAT5B, KMT2A, CREB1, TBL1XR1, EZH2, BMPR1A, GRHL2, ZHX2, SPI1, HES1, HDAC2, GATA2, ZNF644, SIX2, FLI1, NR2C2, MXI1, NCOA2, CC2D1A, RUNX1, BCL6, SMC1A, HDAC1, LDB1, NKX2-2, CEBPA, SIN3A, ZFX, SMAD3, TET2, ERG3, ZMIZ1, MEF2A, CREBBP, ZNF384, ZNF35, ZBTB2, RARA, NOTCH1, RUNX2, GATA4, ARNT, DAXX, PBX4, ZNF48, PRDM9, ZEB2, HMBOX1, CBFA2T3, PBX3, FOXM1, FOS, CDK8, NR2C1, ZNF10, CHD1, MED1, PML, CEBPD, MYB, SCRT2, KDM6B, SMAD1, KLF9, NCOA1, L3MBTL2, EVI1, STAT5A, KLF16, RBM22, USF1, BCL11A, TFAP2A, SP1, REST, ZBTB7A, ATF7, HNRNPLL, TCF3, BCOR, AATF, SMC3, NCOR2, STAG1, MLLT1, TRP47, CBFA2T2, MEF2B, CBX3, MTA3, CREM, RBBP5, FOXA2, AGO1, PAF1, EBF1, WT1, FOXF1, ZBTB33, TCF7, CDK9, ZKSCAN1, KDM1A, YY1, RELA, JUNB, NEUROD1, SP140, ZFP36, TCF4, HIF1A, ZIC2, BHLHE22, GATA3, MGA, TAL1, MAX, SPIB, ZNF143, NRIP1, GATA1, MTA1, AGO2, KLF4, ZNF592, BCL11B, GFI1B, NR2F2, NR2F1, KDM5B, TP53, PKNOX1, ZNF334, EGR2, ELF3, TBX21, BHLHE40, AR, ZBTB16, ZBTB40, YAP1, RXR, HEXIM1, HSF1, NCOR1, MYNN, BRD4, ILF3, JUND, RNF2, SCRT1, MAZ, ZBTB26, ZNF395, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): RSPH1,PDE9A,FAM3B,UMODL1,ABCG1,ZBTB21,SLC37A1,BACE2,C2CD2
- Function elements
- Human SNPs: Gut_microbiota_relative_abundance_(unclassified_genus_belonging_to_family_Erysipelotrichaceae)
- Number of somatic mutations (coding): 154
- Number of somatic mutations (non-coding): 73
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000157617,
ENSG00000173276,
ENSG00000177398,
ENSG00000160179,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
- Related loop:
chr21:41275000-41300000~~chr21:41900000-41925000,
chr21:41650000-41675000~~chr21:41900000-41925000,
chr21:41815737-41818316~~chr21:41895209-41897144,
chr21:41815741-41818325~~chr21:41894768-41897068,
chr21:41875000-41900000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:42000000-42025000,
chr21:41875000-41900000~~chr21:42100000-42125000,
chr21:41900000-41925000~~chr21:42100000-42125000,
chr21:41900000-41925000~~chr21:42275000-42300000,
chr21:41900000-41925000~~chr21:42475000-42500000,
chr21:41900000-41925000~~chr21:42675000-42700000,
chr21:41900000-41925000~~chr21:42750000-42775000,