- Basic information
- CohesinDB ID: CDBP00420183
- Locus: chr21-41903610-41904218
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Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191
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Cell type: RPE, Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 54%,
"4_Tx": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, KDM4B, RBFOX2, PBX2, HDGF, ATF3, SMARCE1, MITF, ETV1, NFE2L2, SMAD5, ESR1, HDAC8, CTCF, DPF2, SOX6, TEAD4, BRD1, ZNF263, MYCN, SRC, ID3, TOP2A, CTBP1, ZBTB48, TBP, OGG1, ETS1, MYC, SMARCA4, ARID1B, GRHL3, GABPA, STAT3, RCOR1, NR2F6, ESRRA, CEBPB, SPI1, HDAC2, MXD3, ATF1, RUNX1, CBX1, HDAC1, ZFX, SMAD3, TET2, RUNX2, ARNT, PRDM9, CBFA2T3, FOS, PML, MYB, TAF7, RBM22, BCL11A, ZBTB7A, HNRNPLL, AATF, SMC3, STAG1, TRP47, AGO1, MTA3, CREM, WT1, ESR2, ZKSCAN1, KDM1A, YY1, RELA, SP140, HIF1A, AGO2, PLAG1, NR2F2, NR2F1, KDM5B, ZNF334, BHLHE40, AR, HSF1, NCOR1, RNF2, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): RSPH1,PDE9A,C2CD2,ABCG1,BACE2,UMODL1,FAM3B,SLC37A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 2
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
- Related loop:
chr21:41275000-41300000~~chr21:41900000-41925000,
chr21:41650000-41675000~~chr21:41900000-41925000,
chr21:41875000-41900000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:42000000-42025000,
chr21:41875000-41900000~~chr21:42100000-42125000,
chr21:41900000-41925000~~chr21:42100000-42125000,
chr21:41900000-41925000~~chr21:42275000-42300000,
chr21:41900000-41925000~~chr21:42475000-42500000,
chr21:41900000-41925000~~chr21:42675000-42700000,
chr21:41900000-41925000~~chr21:42750000-42775000,