- Basic information
- CohesinDB ID: CDBP00420185
- Locus: chr21-41907516-41908154
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Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015
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Cell type: RPE, Fibroblast, HCT-116, RT-112, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 54%,
"5_TxWk": 41%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, XBP1, FOXA1, HLF, SUZ12, ATF3, CBFB, PAX5, TP63, CDX2, ESR1, OCA2, CTCF, PAX8, ZNF808, GATAD2A, POU2F2, MYCN, ZNF263, POU5F1, TOP2A, ZBTB48, ZSCAN5A, ERG, OGG1, MYC, RAD21, GRHL3, RXRA, STAT3, DNMT3B, HNRNPH1, CEBPB, GRHL2, GATA2, FLI1, PTBP1, RUNX1, CEBPA, ZFX, ERG3, PRDM10, ZNF384, CDK6, GATA4, PRDM9, NCAPH2, FOS, MED1, KDM6B, PIAS1, RBM22, SP1, REST, HNRNPLL, AATF, SMC3, STAG1, TRP47, FOXA2, WT1, HOXB13, YY1, RELA, ZNF19, SP140, HIF1A, ZNF143, AGO2, GATA1, TLE3, CEBPG, ZNF141, NCOA3, NR2F2, NR2F1, ZNF334, AR, RXR, HEXIM1, HSF1, ZBTB26, NOTCH3, BRD4, MAZ
- Target gene symbol (double-evidenced CRMs): PDE9A,BACE2,FAM3B,UMODL1,C2CD2,RSPH1,SLC37A1,ABCG1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 86
- Number of somatic mutations (non-coding): 43
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
- Related loop:
chr21:41275000-41300000~~chr21:41900000-41925000,
chr21:41650000-41675000~~chr21:41900000-41925000,
chr21:41900000-41925000~~chr21:42100000-42125000,
chr21:41900000-41925000~~chr21:42275000-42300000,
chr21:41900000-41925000~~chr21:42475000-42500000,
chr21:41900000-41925000~~chr21:42675000-42700000,
chr21:41900000-41925000~~chr21:42750000-42775000,