- Basic information
- CohesinDB ID: CDBP00420189
- Locus: chr21-41916566-41919291
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR000BLY, ENCSR404BPV, GSE111537, GSE25021, GSE108869, GSE115602, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, ENCSR703TNG, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000BMY, ENCSR000EHX, ENCSR000BTQ, ENCSR167MTG, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893
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Cell type: GM10847, GM2610, GM19240, HSPC, HuCC-T1, RPE, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, K-562, GM18486, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, GM19099, Macrophage, MCF-7, GM12892, HCT-116, Hep-G2, Neurons-H1, GM19238, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 21% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.600
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
96% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 48%,
"5_TxWk": 44%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, LDB1, TRP47, PGR, BCL6, PPARG, CEBPA, MYCN, POU5F1, TOP2A, HDAC6, ZFX, RBPJ, XBP1, EBF1, WT1, ZBTB48, SIN3A, TET2, ERG3, DDX5, SAP130, ETV5, SP5, ERG, ZNF19, RELA, KDM1A, ZNF384, OGG1, ZNF341, ATF3, MYC, RAD21, SP140, GRHL3, ZFP36, NKX2-1, ZNF48, CBFB, SMAD4, STAT3, XRCC5, TP63, TAL1, SMARCB1, GATA1, MIER3, DNMT3B, HNRNPH1, RCOR1, MED1, CEBPG, NCOA3, TEAD3, ZNF416, TRIM28, SNAI2, ESR1, CTCF, RBM22, ELF3, MIXL1, HNF4A, ARID4B, RXR, MXD3, HEXIM1, ZBTB26, BRD4, MAZ, AATF, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): UMODL1,SLC37A1,PRDM15,ABCG1,FAM3B,PDE9A,C2CD2,RSPH1,BACE2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 120
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000182240,
ENSG00000183844,
ENSG00000141956,
ENSG00000157617,
ENSG00000177398,
ENSG00000160179,
ENSG00000160188,
ENSG00000160190,
ENSG00000160191,
- Related loop:
chr21:41275000-41300000~~chr21:41900000-41925000,
chr21:41609812-41611395~~chr21:41916134-41918303,
chr21:41611517-41613753~~chr21:41916134-41918303,
chr21:41611530-41614015~~chr21:41916406-41918311,
chr21:41611760-41613474~~chr21:41916617-41917842,
chr21:41650000-41675000~~chr21:41900000-41925000,
chr21:41673182-41674339~~chr21:41916134-41918303,
chr21:41815722-41818125~~chr21:41916406-41918311,
chr21:41815741-41818325~~chr21:41916134-41918303,
chr21:41815772-41818348~~chr21:41916377-41918020,
chr21:41815787-41818293~~chr21:41916417-41918064,
chr21:41900000-41925000~~chr21:42100000-42125000,
chr21:41900000-41925000~~chr21:42275000-42300000,
chr21:41900000-41925000~~chr21:42475000-42500000,
chr21:41900000-41925000~~chr21:42675000-42700000,
chr21:41900000-41925000~~chr21:42750000-42775000,