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Basic information

CohesinDB ID: CDBP00420190

Locus: chr21-41919607-41924881

Data sourse: ENCSR000EFJ, GSE93080, ENCSR230ZWH, GSE67783, GSE86191, GSE98367, ENCSR404BPV, GSE206145, GSE206145-NatGen2015, GSE62063, ENCSR198ZYJ, GSE50893, ENCSR917QNE

Cell type: RPE, Macrophage, Fibroblast, HCT-116, SNYDER, Neurons-H1, GM12878, Ramos, GM12891, IMR-90, GM19239, Liver, HSPC, GM18486, B-cell

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 8% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 96% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 47%, "7_Enh": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NME2, XBP1, FOXA1, SUZ12, RXRB, ZNF28, HDGF, LYL1, ZNF90, NFIC, SETX, PRDM1, MORC2, MECOM, PAX5, TP63, SNAI2, LMO2, ESR1, OCA2, USF2, CTCF, JUN, TCF12, EP300, MNT, RAD51, RBPJ, EED, POU2F2, BRD1, MYCN, ZNF263, TOP2A, POU5F1, ZBTB48, ZSCAN5A, STAT1, ERG, PBX1, ASCL1, MYC, RAD21, RXRA, STAT3, NKX3-1, IKZF1, DNMT3B, NR3C1, KMT2A, CREB1, EZH2, TBL1XR1, GRHL2, SPI1, SSRP1, GATA2, MXD3, SIX2, ZNF554, RUNX1, CBX1, SMC1A, BCL6, NKX2-2, CEBPA, ZFX, TET2, ZNF654, ERG3, TRIM22, ZBTB2, CREBBP, RARA, ZNF184, ARNT, SMAD4, PBX3, ZNF10, FOS, CDK8, TEAD3, ZEB1, MYB, EVI1, STAT5A, RBM22, USF1, BCL11A, SP1, NR4A1, IKZF5, REST, TCF3, BCOR, FOXP1, SMC3, NCOR2, STAG1, MLLT1, SKI, MEF2B, TBL1X, FOXA2, EBF1, PAF1, NFATC1, WT1, ZNF662, ZBTB33, BCL3, KDM1A, YY1, RELA, JUNB, SP140, TCF4, HIF1A, SKIL, BHLHE22, TAL1, MAX, SPIB, ZNF143, GATA1, NCOA3, NR2F2, NR2F1, TP53, PKNOX1, ZNF334, MYOD1, AR, RXR, EGR1, HSF1, ZBTB26, IKZF2, BRD4, NCOR1, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): BACE2,RSPH1,FAM3B,UMODL1,PDE9A,SLC37A1,ABCG1,C2CD2

Function elements

Human SNPs: Tuberculosis

Number of somatic mutations (coding): 92

Number of somatic mutations (non-coding): 43

Related genes and loops

Related gene: ENSG00000182240, ENSG00000183844, ENSG00000157617, ENSG00000177398, ENSG00000160179, ENSG00000160188, ENSG00000160190, ENSG00000160191,

eachgene

Deatailed information for cohesin site CDBP00420190